D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT

D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  D-α-Hydroxyglutaric Acid (D-2-HG) is an α-hydroxy acid that is over-produced in the human neurometabolic disease D-2-hydroxyglutaric aciduria (D-2-HGA). It is normally synthesized from 2-ketoglutarate (2-KG) by hydroxyacid-oxoacid transhydrogenase (HOT), although defects in HOT are not known to be associated with D-2-HGA. Instead, type I D-2-HGA involves mutations in D-2-hydroxyglutarate dehydrogenase, which converts D-2-HG back to 2-KG. Type II D-2-HGA results from gain-of-function mutations in isocitrate dehydrogenase 2, causing it to supplement HOT in converting 2-KG to D-2-HG. In bacteria, this α-hydroxy acid may be synthesized from oxalate and propionyl-coenzyme A by an α-hydroxyglutaric acid synthetase.

• Chemische Eigenschaften

  Pale Orange Solid

• Verwenden

  A potential inhibitor of glutamate carboxypeptidase.

• Biochem/physiol Actions

  Biomarker for inborn errors of metabolism and cancer

• Lager

  Store at -20°C

D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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