3-Amino-6-bromopyrazine-2-carbonitrile

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

3-Amino-6-bromopyrazine-2-carbonitrile Chemische Eigenschaften,Einsatz,Produktion Methoden

• Synthese

  

  25911-65-3

  

  17231-51-5

  Bromine (0.95 mL, 19 mmol) was added slowly and dropwise to a solution of 3-aminopyrazine-2-carbonitrile (1.7 g, 14 mmol) in acetic acid (40 mL) at room temperature. The reaction mixture was heated to 60 °C and held for 30 min, followed by cooling to room temperature. The mixture was poured into ice water and the precipitated solid was collected by filtration. After sufficient washing with water, 3-amino-6-bromopyrazine-2-carbonitrile was obtained as a yellow solid (2.3 g, 83% yield). The product was characterized by 1H NMR (500 MHz, DMSO-d6): δ 8.44 (s, 1H), 7.60 (br s, 2H). Mass spectrum (ES+): m/z 199 (M+H)+.

• Einzelnachweise

  [1] Journal of Organic Chemistry, 1987, vol. 52, # 18, p. 3997 - 4000
  [2] Patent: US2007/259876, 2007, A1. Location in patent: Page/Page column 18

3-Amino-6-bromopyrazine-2-carbonitrile Upstream-Materialien And Downstream Produkte

3-Amino-6-bromopyrazine-2-carbonitrile Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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