LY411575

Bezeichnung:LY411575

CAS-Nr209984-57-6

Englisch Name:LY411575

CBNumberCB22464309

SummenformelC26H23F2N3O4

Molgewicht479.48

MOL-Datei209984-57-6.mol

LY411575 physikalisch-chemischer Eigenschaften

Siedepunkt	836.0±65.0 °C(Predicted)
Dichte	1.40
storage temp.	-20°C
Löslichkeit	DMSO: soluble5mg/mL, clear
Aggregatzustand	powder
pka	11.79±0.20(Predicted)
Farbe	white to beige
InChIKey	ULSSJYNJIZWPSB-CVRXJBIPSA-N

Sicherheit

S-Sätze:	24/25
WGK Germany	3
HS Code	29337900

Gefahreninformationscode (GHS)

LY411575 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
γ-Secretase is a multi-subunit aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. One well-known substrate of this enzyme is Notch, a transmembrane receptor that plays a key role in cell fate decisions including cell proliferation, differentiation, and apoptosis. LY411575 is a cell-permeable γ-secretase inhibitor (IC₅₀ = 0.14 nM) that has been shown to block Notch activation in vitro at 500 μM. LY411575 can induce apoptosis in Kaposi’s sarcoma cells as well as promote intestinal goblet cell differentiation in a mouse model of colitis. It has also been observed to promote neural differentiation of mouse embryonic stem cells.
Verwenden
LY-411575 has been used as a potent γ-secretase inhibitor and Notch inhibitor.
Definition
ChEBI: A dibenzoazepine that is 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one which is substituted at the 7 pro-S position by the C-terminal carboxamide nitrogen of N /element>2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-L-alaninamide. It is a potent, cell permeable and selective gamma-secretase inhibitor. It has been tested as a possible treatment for Alzheimer's disease and shows promise for its potential to counteract severe hearing loss.
Biochem/physiol Actions
LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Studies (Cancer Cell) have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.
target
γ-secretase

LY411575 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

209984-57-6, LY411575 Verwandte Suche:

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