Stiripentol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

• Sicherheit

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

STIRIPENTOL Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Stiripentol is a third-generation antiepileptic compound. It is a positive allosteric modulator of GABA_A receptors, potentiating GABA-mediated activation to a greater extent in receptors expressing α₃ subunits and to a lower extent in those containing β₁ or ε subunits. It also inhibits GABA reuptake in vitro and increases the release of GABA in neonatal rat hippocampal slices. Stiripentol (500 μM) inhibits lactate dehydrogenase (LDH), blocking both lactate-to-pyruvate and pyruvate-to-lactate conversions by human LDH1 and LDH5. Formulations containing stiripentol have been used in the adjunctive treatment of seizures associated with Dravet syndrome.

• Chemische Eigenschaften

  White Solid

• Verwenden

  Stiripentol has been used in pharmacokinetic analysis and as a reference standard in fluorescence spectra analysis.

• Verwenden

  An antiepileptic drug

• Verwenden

  Stiripentol is an epilepsy drug, it has been used as co-therapy for treatment of epilepsy.

• Definition

  ChEBI: 1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol is a phenylpropanoid.

• Biochem/physiol Actions

  Anti-convulsant drug

STIRIPENTOL Upstream-Materialien And Downstream Produkte

Stiripentol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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