5-Chloroindole Struktur

5-Chlorindol

Bezeichnung:5-Chlorindol

CAS-Nr17422-32-1

Englisch Name:5-Chloroindole

CBNumberCB2126773

SummenformelC8H6ClN

Molgewicht151.59

MOL-Datei17422-32-1.mol

Synonyma

5-Chlorindol

5-Chlorindol physikalisch-chemischer Eigenschaften

Schmelzpunkt	69-71 °C (lit.)
Siedepunkt	130 °C / 0.4mmHg
Dichte	1.1976 (rough estimate)
Brechungsindex	1.5437 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Soluble in alcohol.
pka	16.09±0.30(Predicted)
Aggregatzustand	Crystalline Powder
Farbe	White to slightly grayish-green
BRN	2651
InChIKey	MYTGFBZJLDLWQG-UHFFFAOYSA-N
CAS Datenbank	17422-32-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	36/37/38-20/21/22
S-Sätze:	22-24/25-36-26-37/39
RIDADR	2811
WGK Germany	3
F	10
HazardClass	IRRITANT
HS Code	29339990

Gefahreninformationscode (GHS)

5-Chloroindole Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
White to slightly greyish-green crystalline powder
Verwenden
5-Chloroindole is a halo-substituted indole used in the preparation of neurologically active compounds such as atypical antipsychotic agents. 5-Chloroindole has been shown to depress serotonin levels in the brainstem and telencephalon.
Verwenden
5-Chloroindole has been used in the synthesis of 5-chloro-3-indole-N,N- dimethylglyoxalamide and 5-chloro-N,N-dimethyltryptamine. It may be used in the synthesis of dyestuffs in the presence of biocatalysts. 5-Chloroindole can be synthesized by using 3-chlorobenzaldehyde as starting reagent
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 29, p. 1625, 1992 DOI: 10.1002/jhet.5570290644
The Journal of Organic Chemistry, 44, p. 578, 1979 DOI: 10.1021/jo01318a021
Allgemeine Beschreibung
5-Chloroindole is a 5-substituted indole. It undergoes electropolymerization to form a redox-active film consisting of a cyclic trimer and chains of linked cyclic trimer (polymer). It is a potential positive allosteric modulator (PAM) of the 5-HT₃ receptor. It has been reported as strong inhibitor of the copper dissolution in acidic sodium chloride solution. It has been tested as corrosion inhibitor of mild steel in 1N deaerated sulphuric acid. Synthesis of 5-chloroindole, via nitration of indoline has been described.
läuterung methode
It is distilled at high vacuum and recrystallises from pet ether (b 40-60o) or (b 80-100o) as glistening plates. The picrate has m 147o (146.5-147.5o)(from *C6H6). [Rydon & Tweddle J Chem Soc 3499 1955, Sugasawa J Org Chem 44 578 1979, Beilstein 20/4 V 34.]

5-Chloroindole Upstream-Materialien And Downstream Produkte

5-Chlorindol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

17422-32-1, 5-Chloroindole Verwandte Suche:

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