Herbacetin

Bezeichnung:Herbacetin

CAS-Nr527-95-7

Englisch Name:Herbacetin

CBNumberCB21074417

SummenformelC15H10O7

Molgewicht302.24

MOL-Datei527-95-7.mol

Herbacetin physikalisch-chemischer Eigenschaften

Schmelzpunkt	284℃
Siedepunkt	618.7±55.0 °C(Predicted)
Dichte	1.799
storage temp.	-20°C
Löslichkeit	DMF:30.0(Max Conc. mg/mL);99.26(Max Conc. mM) DMSO:30.0(Max Conc. mg/mL);99.26(Max Conc. mM) DMSO:PBS(pH 7.2) (1:4):1.0(Max Conc. mg/mL);3.31(Max Conc. mM) Ethanol:2.0(Max Conc. mg/mL);6.62(Max Conc. mM)
Aggregatzustand	A crystalline solid
pka	6.49±0.40(Predicted)
Farbe	Light yellow to yellow
LogP	1.140 (est)

Gefahreninformationscode (GHS)

Herbacetin Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Soluble in methanol, ethanol, DMSO and other organic solvents, derived from the aerial part of Equisetum, Rhodiola rosea.
Verwenden
Herbacetin is a flavonol compound, and a natural inhibitor of E.coli β-glucuronidase. Herbacetin inhibits inducible nitric oxide synthase via JNK and nuclear factor-κB in LPS-stimulated RAW264.7 cells. Molecular docking study of flavonoid compounds as an inhibitor of β-ketoacyl acyl carrier proteinsynthase II of Pseudomonas aeruginosa.
Definition
ChEBI: Herbacetin is a pentahydroxyflavone that is kaempferol substituted by a hydroxy group at position 8. It is a natural flavonoid from flaxseed which exerts antioxidant, anti-inflammatory and anticancer activities. It has a role as an EC 4.1.1.17 (ornithine decarboxylase) inhibitor, an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor, a plant metabolite, an antilipemic drug, an anti-inflammatory agent and an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor. It is a pentahydroxyflavone and a 7-hydroxyflavonol. It is functionally related to a kaempferol.
Biologische Aktivität
Herbacetin is a natural flavonoid in flaxseed with a variety of pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects. Gluprotamine is an allosteric inhibitor of Ornithine decarboxylase (ODC), which directly binds to Asp44, Asp243 and Glu384 on ODC.
in vivo

Herbacetin (orally administration; 20mg/kg) significantly reduces the body weight, plasma glucose, plasma insulin, and HOMA-IR activity in obesity associated insulin resistant mice (OIR). (Herbacetin dissolves in 0.5% DMSO) .Herbacetin (intraperitoneal injection; 0.4, 2, 10 or 20 mg/kg; BW) decreases the number and size of polyps in APCM ⁱⁿ⁺ mice with no overt toxicity.

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Herbacetin Upstream-Materialien And Downstream Produkte

Herbacetin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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