1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE

Bezeichnung:1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE

CAS-Nr73465-43-7

Englisch Name:1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE

CBNumberCB1768822

SummenformelC6H14ClNO4

Molgewicht199.63

MOL-Datei73465-43-7.mol

1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	183-185°C
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	H2O: soluble10mg/mL
Aggregatzustand	Powder
Farbe	white to off-white
Wasserlöslichkeit	Soluble in water (50 mM)
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
CAS Datenbank	73465-43-7

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	20/21/22-36/37/38
S-Sätze:	22-24/25-36-37/39-26
WGK Germany	3
HS Code	2941900000

Gefahreninformationscode (GHS)

1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
1-Deoxymannojirimycin is a specific inhibitor of class I α-1,2-mannosidase (IC₅₀ = 0.02 μM), a key enzyme for N-glycan processing in the endoplasmic reticulum and Golgi and for targeting misfolded proteins for translocation out of the endoplasmic reticulum and degradation by the proteasome. By inhibiting α-1,2-mannosidase activity, this compound generates N-linked oligosaccharides with high mannose content, preventing misfolded protein degradation. This compound has been used for studies on glycoprotein processing and as a model for the development of anticancer and antiviral therapies.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
Deoxymannojirimycin has been shown to be a potent inhibitor of the mammalian Golgi alpha- mannosidase 1 activity, blocking the conversion of high-mannose oligosaccharides to complex-type oligosaccharides. However, it does not inhibit the biosynthesis of lipid- linked oligosaccharides.
Verwenden
Selective inhibitor of a-mannosidase
Lager
+4°C
Einzelnachweise
1) Bischoff et al. (1986), The use of 1-deoxymannojirimycin to evaluated the role of various alpha-mannosidases in oligosaccharide processing in intact cells; J. Biol. Chem., 261 4766 2) Bischoff et al. (1984), The effect of 1-deoxymannojirimycin on rat liver alpha mannosidases.; Biochem. Biophys. Res. Commun., 125 324 3) Fuhrmann et al. (1984), Novel mannosidase inhibitor blocking conversation of high mannose to complex oligosaccharides; Nature, 307 755 4) Miyake and Nagai (2009), Inhibition of alpha-mannosidase attenuates endoplasmic reticulum stress-induced neuronal cell death; Neurotoxicology, 30 144 5) Tai et al. (2011), Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian? cells; J. Biol. Eng., 5? 1 6) Lee et al. (2012), Construction of stable producer cells to make high-titer lentiviral vectors for dendritic cell-based vaccination; Biotechnol. Bioeng., 109 1551

1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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