Paroxetine maleate

Bezeichnung:Paroxetine maleate

CAS-Nr64006-44-6

Englisch Name:Paroxetine maleate

CBNumberCB1712562

SummenformelC23H24FNO7

Molgewicht445.44

MOL-Datei64006-44-6.mol

Paroxetine maleate physikalisch-chemischer Eigenschaften

Schmelzpunkt	136-138°C
alpha	D -87° (c = 5 in ethanol)
Flammpunkt	9℃
storage temp.	2-8°C
Löslichkeit	DMSO: ~12 mg/mL
Aggregatzustand	solid
Farbe	white

Sicherheit

Kennzeichnung gefährlicher	Xn,T,F
R-Sätze:	22-36/37/38-39/23/24/25-23/24/25-11
S-Sätze:	26-36-45-36/37-16-7
RIDADR	3249
WGK Germany	3
RTECS-Nr.	TM4569300
HazardClass	6.1(b)
PackingGroup	III
Toxizität	LD50 in mice (mg/kg): 845 s.c.; 500 orally (Christensen, Squires, 1977)

Gefahreninformationscode (GHS)

Paroxetine maleate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
Paroxetine maleate is a selective serotonin uptake inhibitor.
Definition
ChEBI: A maleate salt obtained by reaction of paroxetine with one equivalent of maleic acid. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibi ion of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2
Allgemeine Beschreibung
Paroxetine, marketed under trade names such as Paxil^? or Aropax, is an SSRI antidepressant used to treat many conditions in adults from major depression and obsessive-compulsive disorder to several anxiety disorders. Suitable uses for this certified solution standard include as a starting material for calibrators and controls in LC/MS or GC/MS paroxetine testing applications such as urine drug testing, prescription monitoring, clinical toxicology, or forensic analysis.
Biologische Aktivität
Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (K i = 0.05 nM). K i values are 1.1, 350 and 1100 nM for inhibition of [ 3 H]-5-HT, [ 3 H]-l-NA and [ 3 H]-DA uptake respectively. Displays minimal affinity for a 1 -, a 2 - or b-adrenoceptors, 5-HT 2A , 5-HT 1A , D 2 or H 1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (K i = 42 nM). Antidepressant and anxiolytic in vivo .
Biochem/physiol Actions
Paroxetine is a strong cytochrome P450 2D6 isotype (CYP2D6) inhibitor, which reduces the effectiveness of tamoxifen. This phenylpiperidine derivative inhibits clozapine metabolism. Paroxetine is used to treat social phobia, obsessive-compulsive disorder and panic disorder. It is also used to treat the premenstrual dysphoric disorder, post-traumatic stress disorder and chronic headache.
Lager
Store at RT

Paroxetine maleate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

64006-44-6, Paroxetine maleate Verwandte Suche:

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