NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Struktur

NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE

Bezeichnung:NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE

CAS-Nr220805-22-1

Englisch Name:NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE

CBNumberCB1706734

SummenformelC8H20Cl2N4O2

Molgewicht275.18

MOL-Datei220805-22-1.mol

NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	202-204OC
storage temp.	room temp
Löslichkeit	DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
Aggregatzustand	White to off-white crystalline solid.
Farbe	White to Off-White
Wasserlöslichkeit	Soluble in water (100 mM)
Stabilität	Store at 0-5°C; Moisture Sensitive; Hygroscopic
CAS Datenbank	220805-22-1

Sicherheit

WGK Germany

NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White Crystalline Solid
Verwenden
N^G,N^G- Dimethylarginine dihydrochloride has been used:
- to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats
- as a standard for measuring L-arginine and dimethylarginines
- to study its effects on hepatic deterioration
Verwenden
A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells
Allgemeine Beschreibung
N^G,N^G-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).
Biologische Aktivität
ng,ng-dimethyl-l-arginine is an endogenous nitric oxide synthase inhibitor.nitric oxide (no) that is synthesised from l-arginine contributes to the regulation of blood pressure and to host defence.
Biochem/physiol Actions
Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.
in vitro
ng,ng-dimethyl-l-arginine (adma) was found to be able to inhibit macrophage and vascular no synthase. when added to a cytosolic preparation of macrophage no synthase, adma could cause dose-dependent inhibition of no formation. in the presence of added arginine, adma could inhibited no synthesis and the inhibitory effects of adma were prevented by addition of l-arginine so that the rate of no synthesis did not significantly differ from control values [1].
in vivo
animal study showed that the injection of 1-30 mg/kg adma into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. moreover, during continuous infusion of adma, which caused plasma adma concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1].
Lager
Room temperature (desiccate)
Einzelnachweise
[1] vallance, p. ,leone, a.,calver, a., et al. accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. lancet 339, 572-575 (1992).

NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

220805-22-1, NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE Verwandte Suche:

Send Inquriy