RA-9 Struktur

RA-9

Bezeichnung:RA-9

Englisch Name:RA-9

CBNumberCB16188329

SummenformelC19H15N3O5

Molgewicht365.34

RA-9 physikalisch-chemischer Eigenschaften

Schmelzpunkt	230-233 °C(Solv: ethyl ether (60-29-7); acetonitrile (75-05-8))
Siedepunkt	588.5±50.0 °C(Predicted)
Dichte	1.414±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
Löslichkeit	DMSO: 4.17 mg/mL (11.41 mM; ultrasonic and warming and heat to 80°C)
pka	5.13±0.20(Predicted)
Aggregatzustand	Solid
Farbe	Light yellow to yellow

Gefahreninformationscode (GHS)

Biologische Aktivität
RA-9 is a potent and selective inhibitor of cell-permeable proteasome-associated deubiquitinating enzymes (DUBs) with favorable toxicity and anticancer activity. It selectively induces apoptosis in ovarian cancer cell lines.
in vivo

RA-9 (5 mg/kg; ip; one-day on, two-days off) inhibits human ovarian cancer cell growth in vivo and prolongs survival in a mouse model for ovarian cancer.

< td class="col1 fwb"> Animal Model:

Six-week-old female immunodeficient (NCr nu/nu) mice

Dosage: 5 mg/kg

Administration: Ip; one-day on, two-days off

Result: Significant reduction in tumor burden at day 12.

target

Target	Value
DUBs ()

Six-week-old female immunodeficient (NCr nu/nu) mice
Dosage:	5 mg/kg
Administration:	Ip; one-day on, two-days off
Result:	Significant reduction in tumor burden at day 12.