2-(β-D-Ribofuranosyl)-1,2,4-triazin-3,5-diol

Bezeichnung:2-(β-D-Ribofuranosyl)-1,2,4-triazin-3,5-diol

CAS-Nr54-25-1

Englisch Name:6-AZAURIDINE

CBNumberCB1413830

SummenformelC8H11N3O6

Molgewicht245.19

MOL-Datei54-25-1.mol

Synonyma

2-(β-D-Ribofuranosyl)-1,2,4-triazin-3,5-diol

2-(β-D-Ribofuranosyl)-1,2,4-triazin-3,5-diol physikalisch-chemischer Eigenschaften

Schmelzpunkt	157-159 °C(lit.)
Siedepunkt	388.15°C (rough estimate)
Dichte	1.4866 (rough estimate)
Brechungsindex	1.7950 (estimate)
storage temp.	2-8°C
Löslichkeit	DMSO (Slightly, Heated), Methanol (Slightly, Heated), Pyridine (Slightly), Water
Aggregatzustand	Powder
pka	6.70(at 25℃)
Farbe	White
Wasserlöslichkeit	It is soluble in water.
Merck	14,904
Stabilität	Hygroscopic
InChIKey	WYXSYVWAUAUWLD-YGWZKZRUSA-N
CAS Datenbank	54-25-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-40
S-Sätze:	22-36
WGK Germany	3
RTECS-Nr.	XY8575000
HS Code	29349990
Giftige Stoffe Daten	54-25-1(Hazardous Substances Data)
Toxizität	LD50 oral in quail: > 316mg/kg

Gefahreninformationscode (GHS)

6-AZAURIDINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White powder
Verwenden
6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP and it is used in antiviral studies.
Verwenden
6-Azauridine can be applied in antiviral studies. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis. It is also used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.
Verwenden
Research on cell formation and cancer.
Definition
ChEBI: 6-azauridine is a N-glycosyl-1,2,4-triazine. It has a role as an antineoplastic agent, an antimetabolite and a drug metabolite.
Allgemeine Beschreibung
6-Azauridine is a pyrimidine nucleoside analog.
Biochem/physiol Actions
6-azauridine is a prodrug, upon conversion to 6-aza-UMP, inhibits uridine monophosphate synthase (UMPS). It is a broad spectrum anti-metabolite. It interferes with pyrimidine biosynthesis and affects the cellular nucleic acid levels. It is considered as a antineoplastic metabolite. It inhibits RNA viruses like chikungunya virus, semliki forest virus, and human coronavirus. It significantly inhibits the growth of Cryptosporidium parasites.

2-(β-D-Ribofuranosyl)-1,2,4-triazin-3,5-diol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

54-25-1, 6-AZAURIDINE Verwandte Suche:

Send Inquriy