PHENCYCLIDINE

Bezeichnung:PHENCYCLIDINE

CAS-Nr77-10-1

Englisch Name:PHENCYCLIDINE

CBNumberCB1310072

SummenformelC17H25N

Molgewicht243.39

MOL-Datei77-10-1.mol

PHENCYCLIDINE physikalisch-chemischer Eigenschaften

Schmelzpunkt	46.5℃
Siedepunkt	bp1.0 135-137°
Dichte	0.9762 (rough estimate)
Brechungsindex	1.5000 (estimate)
Flammpunkt	11 °C
storage temp.	−20°C
pka	pKa 8.5 (Uncertain)
Farbe	Colorless crystals
EPA chemische Informationen	Piperidine, 1-(1-phenylcyclohexyl)- (77-10-1)

Sicherheit

Kennzeichnung gefährlicher	F,T
R-Sätze:	23/24/25-39/23/24/25-11-61
S-Sätze:	36/37-45-16-53
RIDADR	2811
WGK Germany	1
HazardClass	6.1(a)
PackingGroup	I
Giftige Stoffe Daten	77-10-1(Hazardous Substances Data)
Toxizität	LD50 oral in mouse: 75mg/kg

Gefahreninformationscode (GHS)

PHENCYCLIDINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Verwenden
Anesthetic.
Definition
ChEBI: A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.
Trademarks
Sernylan (Parke-Davis).
Allgemeine Beschreibung
Phencyclidine was introduced as a dissociative anestheticfor animals. Its close structural relative ketamine is still soused and may be used in humans. In humans,PCP produces a sense of intoxication, hallucinogenic experiencesnot unlike those produced by the anticholinergic hallucinogens,and often, amnesia.
The drug affects many systems, including those of NE,DA, and 5-HT. It has been proposed that PCP (and certainother psychotomimetics) produces a unique pattern of activationof ventral tegumental area dopaminergic neurons.Itblocks glutaminergic N-methyl-D-aspartate receptors.Thisaction is the basis for many of its CNS effects. PCP itself appearsto be the active agent. The psychotic state produced bythis drug is also cited as a better model than amphetaminepsychosis for the psychotic state of schizophrenia.
Pharmakologie
PCP acts as a biocide through its ability to uncouple mitochondrial oxidative phosphorylation.
Sicherheitsprofil
Poison by intraperitoneal route. Experimental reproductive effects. Caution: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.12 (1985). The ethylamine, pyrrolidine and thiophene analogs are l
Stoffwechselwegen
When mice and rats are administered phencyclidine intraperitoneally, several hydroxylated metabolites are identified in the urine. A new metabolite, 1-phenyl-1- (1-piperidinyl-3-ol)cyclohexane, is identified in the urine and liver microsomal preparations.
Stoffwechsel
Pentachlorophenolwas metabolized in rats by conjugation with glucuronic acid and eliminated as the glucuronide. P450 catalyzed oxidative dechlorination also occurred to form tetrachlorohydroquinone, and this was conjugated to form a monoglucuronide representing 27% of the dose administered. Other metabolites have been reported, including isomeric tetrachlorophenols, tetrachlorocatechol and tetrachlororesorcinol. Trace amounts of benzoquinones were also noted.
Metabolites in female rats were tetrachloromonophenols, diphenols, and hydroquinones.
Toxicity evaluation
The toxicology has been addressed in a recent risk assessment (119). Acutely, pentachlorophenol was reported to have LD₅₀ values in the rat of 12 mg/kg (inhalation) and 146 mg/kg (M)–175 mg/kg (F) by oral gavage. More detailed studies of the toxicology of pentachlorophenol have been compromised by the toxicity of impurities present in most of the earlier samples used in the evaluation process.

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