ARACHIDOYL ETHANOLAMIDE Struktur

ARACHIDOYL ETHANOLAMIDE

Bezeichnung:ARACHIDOYL ETHANOLAMIDE

CAS-Nr94421-69-9

Englisch Name:ARACHIDOYL ETHANOLAMIDE

CBNumberCB1280650

SummenformelC22H45NO2

Molgewicht355.6

MOL-Datei94421-69-9.mol

ARACHIDOYL ETHANOLAMIDE physikalisch-chemischer Eigenschaften

Löslichkeit	DMF: 10 mg/ml; DMSO: 20 mg/ml; Ethanol: 2.5 mg/ml; PBS (pH 7.2): .15 mg/ml
Aggregatzustand	A crystalline solid

ARACHIDOYL ETHANOLAMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
The endocannabinoids present a rich system of central cannabinoid (CB₁), peripheral cannabinoid (CB₂), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.^1,2 Arachidoyl ethanolamide is one of the saturated fatty acyl ethanolamides devoid of classical (CB₁/CB₂) activity. Arachidoyl ethanolamide does not bind to the murine CB₁ receptor³ and does not compete with anandamide as a substrate for the endocannabinoid hydrolytic enzyme fatty acid amide hydrolase.⁴ Non-CB receptor-mediated pharmacology of the saturated ethanolamides is still being elucidated.⁵
Definition
ChEBI: N-(icosanoyl)ethanolamine is an N-(long-chain-acyl)ethanolamine that is the ethanolamide of eicosanoic acid. It is a N-(long-chain-acyl)ethanolamine and a N-(saturated fatty acyl)ethanolamine. It is functionally related to an icosanoic acid.
Einzelnachweise
1. Martin, B.R., Mechoulam, R., and Razdan, R.K. Discovery and characterization of endogenous cannabinoids Life Sci. 65,573-595(1999).
2. Pertwee, R.G. Pharmacology of cannabinoid receptor ligands Curr. Med. Chem. 6(8),635-664(1999).
3. Sheskin, T., Hanus, L., Slager, J., et al. Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor J. Med. Chem. 40,659-667(1997).
4. Desarnaud, F., Cadas, H., and Piomelli, D. Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization J. Biol. Chem. 270(11),6030-6035(1995).
5. Smart, D., Jonsson, K.O., Vandevoorde, S., et al. “Entourage” effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism Br. J. Pharmacol. 136,452-458(2002).

ARACHIDOYL ETHANOLAMIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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