Apremilast

Bezeichnung:Apremilast

CAS-Nr608141-41-9

Englisch Name:Apremilast

CBNumberCB12563430

SummenformelC22H24N2O7S

Molgewicht460.5

MOL-Datei608141-41-9.mol

Apremilast physikalisch-chemischer Eigenschaften

Schmelzpunkt	152-156°C
Siedepunkt	741.3±60.0 °C(Predicted)
Dichte	1.381
storage temp.	Refrigerator
Löslichkeit	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
pka	14.01±0.20(Predicted)
Aggregatzustand	Solid
Farbe	White to Pale Yellow
InChIKey	IMOZEMNVLZVGJZ-QGZVFWFLSA-N
SMILES	C(NC1=CC=CC2=C1C(=O)N([C@@H](C1=CC=C(OC)C(OCC)=C1)CS(C)(=O)=O)C2=O)(=O)C
CAS Datenbank	608141-41-9

Sicherheit

Giftige Stoffe Daten

608141-41-9(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Apremilast Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Apremilast is the first and only oral phosphodiesterase IV (PDE- 4) inhibitor and anti-tumor necrosis factor alpha (TNFa) agent launched in the USA by Celgene for the treatment of active psoriatic arthritis (PsA). Apremilast was also approved for the treatment of moderate to severe plaque psoriasis in the USA. Later, this drug was also approved in the European Union (EU) for both indications. Although multiple approaches to the synthesis of apremilast have been described, the most likely process scale approach involves the construction of the challenging stereogenic benzylic carbon center by catalytic asymmetric hydrogenation.
Verwenden
Apremilast is an oral phosphodiesterase 4 inhibitor used in the treatment of adults with active psoriatic arthritis and adults with moderate to severe plaque psoriasis.
Definition
ChEBI: Apremilast is a member of the class of isoindoles that is isoindole-1,3-dione substituted at position 4 by an acetamido group and at position 1 by a 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl group. Used for treatment of psoriatic arthritis. It has a role as a phosphodiesterase IV inhibitor and a non-steroidal anti-inflammatory drug. It is an aromatic ether, a N-acetylarylamine, a sulfone and a member of phthalimides.
Clinical Use
Treatment of active psoriatic arthritis (PsA) and moderate to severe chronic plaque psoriasis (PSOR)
Synthese
Dimethyl sulfone was first subjected to n-butyllithium in tetrahydrofuran (THF) prior to exposure to commercially available 3-ethoxy-4-methoxybenzonitrile (15) at low temperature to afford enamine 16 in 83% yield, presumably as a single isomer enamine possessing the E-configuration. After considerable studies conducted by researchers at Celgene regarding the reduction of this enamine and alternative substrates, enamine 16 was reduced under asymmetric hydrogenation conditions consisting of [Rh (COD)2]OTf and (S,R)-t-Bu Josiphos in trifluoroethanol (TFE) at 50 ?? under 90 psi of hydrogen pressure. Immediate exposure of the product to N-acetyl-L-leucine in methanol afforded the corresponding benzylamine salt 18 in 80% yield and more than 99% enantiomeric excess (ee). Finally, compound 18 was condensed with commercially available N-(phthalimid-3-yl)acetamide (19) in refluxing acetic acid to provide apremilast (III) in 83% yield and 99.4% ee.
Überdosierung
Apremilast was studied in healthy subjects at a maximum total daily dose of 100 mg (given as 50 mg twice daily) for 4.5 days without evidence of dose limiting toxicities. In case of an overdose, it is recommended that the patient is monitored for any signs or symptoms of adverse effects and appropriate symptomatic treatment is instituted. In the event of overdose, symptomatic and supportive care is advised.
Enzyminhibitor
This thalidomide-like psoriasis drug (FW = 460.50 g/mol; CAS 608141-41-9; Solubility: 90 mg/mL DMSO; <1 mg/mL H2O), also known as CC-10004, Otezla? and N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methyl-sulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide, is a potent, orally active phosphodiesterase inhibitor that targets phosphodiesterase PDE4 (IC50 = 74 nM), itself a proinflammatory mediator, and TNF-α, IC50 = 77 nM. Apremilast inhibits PBMC production of the chemokines CXCL9 and CXCL10, cytokines interferon-γ and tumor necrosis factor-α (TNF-α), and interleukins IL-2, IL-12 and IL- 23 from human rheumatoid synovial membrane cultures. Apremilast significantly reduces clinical scores in both murine models of arthritis over a ten-day treatment period and maintains healthy joint architecture in a dose-dependent manner. Unlike rolipram, however, apremilast demonstrated no adverse behavioral effects in na?ve mice. Otezla is specifically indicated by the Food & Drug Administration for the treatment of patients with moderate to severe plaque psoriasis who are typically candidates for phototherapy or systemic therapy. That said, the specific mechanism(s) for therapeutic action in psoriatic arthritis patients and psoriasis patients is unclear.
target
PDE4
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Antibacterials: concentration reduced by rifampicin - avoid.
Antidepressants: concentration possibly reduced by St John’s wort - avoid.
Antiepileptics: concentration possibly reduced by carbamazepine, fosphenytoin, phenobarbital, phenytoin and primidone - avoid.
Stoffwechsel
Apremilast is extensively metabolised by both CYP and non-CYP mediated pathways including oxidation, hydrolysis, and conjugation, suggesting inhibition of a single clearance pathway. After oral administration of radiolabelled apremilast, about 3% and 7% of the radioactive dose is recovered as apremilast in urine and faeces, respectively.
Mode of action
Apremilast, an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4), works intracellularly to modulate a network of pro-inflammatory and anti-inflammatory mediators. PDE4 is a cyclic adenosine monophosphate (cAMP)-specific PDE and the dominant PDE in inflammatory cells. PDE4 inhibition elevates intracellular cAMP levels, which in turn down-regulates the inflammatory response by modulating the expression of TNF-α, IL-23, IL-17 and other inflammatory cytokines. Cyclic AMP also modulates levels of anti-inflammatory cytokines such as IL-10. These pro- and anti-inflammatory mediators have been implicated in psoriatic arthritis and psoriasis.

Apremilast Upstream-Materialien And Downstream Produkte

Apremilast Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

608141-41-9, Apremilast Verwandte Suche:

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