N3-PEG3-tBu

N3-PEG3-tBu Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Azido-PEG3-t-butyl ester is a click chemistry reagent. The hydrophilic PEG spacer increases solubility in aqueous media. The azide (N3) group canis reactive with alkyne, such as BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

• Verwenden

  Azido-PEG3-t-butyl Ester is used as a linker in the conjugation of peptides.

• Biologische Aktivität

  N3-PEG3-tBu is a cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). It is also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used to synthesize PROTAC molecules.

• in vitro

  ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
  PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

• target

  PEGs

  Alkyl/ether

  Cleavable

N3-PEG3-tBu Upstream-Materialien And Downstream Produkte

N3-PEG3-tBu Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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