ChemicalBook Produktkatalog Bio- und Chemieingenieurwesen Inhibitoren PI3K / Akt / mTOR PI3K-Inhibitoren N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide

N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide Struktur

N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide

Bezeichnung:N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide

CAS-Nr677338-12-4

Englisch Name:N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide

CBNumberCB12484696

SummenformelC18H17N5O3

Molgewicht351.36

MOL-Datei677338-12-4.mol

N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide physikalisch-chemischer Eigenschaften

Dichte	1.42±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
Löslichkeit	insoluble in DMSO
Aggregatzustand	solid
pka	9.52±0.20(Predicted)
Farbe	Off-white to yellow
CAS Datenbank	677338-12-4

Gefahreninformationscode (GHS)

N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
PIK-90 is a PI3Kα/γ/δ inhibitor, less potent to PI3Kβ.
Definition
ChEBI: N-(7,8-dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide is a member of quinazolines.
Biologische Aktivität
pik-90 is a broad-spectrum pi3k inhibitors that inhibits pi3kα, pi3kγ and pi3kδ with ic50 values of 11, 18 and 58nm, respectively [1].studies showed that pik-90 induced increased levels of secreted ige at 1 μmol/l, while it inhibited ige production at doses of greater than 2 μmol/l [2]. pik-90 has been reported to block akt phosphorylation. pik-90 combined with the cdk2 inhibitor has been demonstrated to induce apoptosis in ln229 ptenwt cells. in addition, pik-90 combined with sirna against both cdk1 and cdk2 has shown to induce cell death, whereas pik-90 combined with sirna against cdk1 or cdk2 had no apoptotic effect [3].
in vivo
pik-90 combined with roscovitine revealed a significant reduction of tumor size in nude mice implanted with gbm43 cells [3].
target
p110α
Lager
Store at -20°C
Einzelnachweise
[1] van keymeulen a1, wong k, knight za, govaerts c, hahn km, shokat km, bourne hr. to stabilize neutrophil polarity, pip3 and cdc42 augment rhoa activity at the back as well as signals at the front. j cell biol. 2006 jul 31;174(3):437-45. epub 2006 jul 24.
[2] zhang tt1, okkenhaug k, nashed bf, puri kd, knight za, shokat km, vanhaesebroeck b, marshall aj. genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances ige production. j allergy clin immunol. 2008 oct;122(4):811-819.e2.
[3] cheng ck1, gustafson wc, charron e, houseman bt, zunder e, goga a, gray ns, pollok b, oakes sa, james cd, shokat km, weiss wa, fan qw. dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. proc natl acad sci u s a. 2012 jul 31;109(31):12722-7.

N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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