VAMICAMIDE

VAMICAMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Vamicamide,Fujisawa Pharmaceutical

• Verwenden

  Antiepileptic; anticonvulsant.

• Manufacturing Process

  Conc. sulfuric acid (11 ml) was added to 4-(N,N-dimethylamino)-2-phenyl-2- (2-pyridyl)-valeronitrile (6.3 g) at 0°C. Then water (1 ml) was added thereto. After being heated at 90°C for 3 hours, the mixture was poured into ice-water, adjusted to pH 10 with 10% aqueous sodium hydroxide and extracted with ethyl acetate (3x50ml). The extracts were combined, and washed with water, dried over magnesium sulfate and evaporated under reduced pressure. The obtained crude crystal was recrystallized from diethyl ether to give 4-(N,N_x0002_dimethylamino)-2-phenyl-2-(2-pyridyl)-valeramide (1.89 g). MP: 132-134°C. Recrystallization from 40% water ethanol gave MP: 156-157°C. The structure of the product was confirmed by UR, NMR (CDCl3) spectra and elemental analysis.

• Therapeutic Function

  Anticholinergic, Spasmolytic

VAMICAMIDE Upstream-Materialien And Downstream Produkte

VAMICAMIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(2)Suppliers

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