Bucetin

Bezeichnung:Bucetin

CAS-Nr1083-57-4

Englisch Name:3-HYDROXY-P-BUTYROPHENETIDINE

CBNumberCB1168297

SummenformelC12H17NO3

Molgewicht223.27

MOL-Datei1083-57-4.mol

Synonyma

Bucetin

Bucetin physikalisch-chemischer Eigenschaften

Schmelzpunkt	160 °C
Siedepunkt	364.56°C (rough estimate)
Dichte	1.1223 (rough estimate)
Brechungsindex	1.5300 (estimate)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
pka	14.07±0.70(Predicted)
Farbe	White to Off-White
Merck	14,1458
CAS Datenbank	1083-57-4
EPA chemische Informationen	Butanamide, N-(4-ethoxyphenyl)-3-hydroxy- (1083-57-4)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	45-46-20/21/22
S-Sätze:	53-22-36/37/39-45
WGK Germany	3
RTECS-Nr.	EU0900000
HS Code	2924.29.7790
Toxizität	LD50 in mice (mg/kg): 790 i.p., 2800 orally (Fujimura)

Gefahreninformationscode (GHS)

3-HYDROXY-P-BUTYROPHENETIDINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R45:Kann Krebs erzeugen.
R46:Kann vererbbare Schäden verursachen.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Originator
Bucetin,ZYF Pharm Chemical
Verwenden
Bucetin is an antipyretic and analgesic drug that is chemically similar to phenacetin. The use of Bucetin has been withdrawn due to renal toxicity.
Verwenden
3-Hydroxy-p-butyrophenetidine is an antipyretic and analgesic drug that is chemically similar to phenacetin (P294580). The use of 3-Hydroxy-p-butyrophenetidine has been withdrawn due to renal toxicity.
Definition
ChEBI: Bucetin is an organic molecular entity.
Manufacturing Process
Bucetin may be prepared from acetoacetic acid p-phenetidide as follows: 5.5 parts of acetoacetic acid p-phenetidide, suspended in 600 parts by volume of methanol, are hydrogenated at 80°-85°C with a nickel catalyst supported on kiesel-guhr. When the theoretical quantity of hydrogen has been absorbed, the solution is cooled, then filtered, and the filtrate is concentrated. The solid residue is recrystallized from six times its weight of isopropanol. β- Hydroxybutyric acid p-phenetidide is obtained in an almost quantitative yield in the form of white crystals which melt at 160°C.
55 parts of acetoacetic acid p-phenetidide, suspended in 500 parts by volume of methanol, are hydrogenated with Raney nickel at 70°C. When the theoretical quantity of hydrogen has been absorbed, the solution is cooled, then filtered, and the filtrate is concentrated. The solid residue is recrystallized from six times its weight of isopropanol. 51 parts (93 % of the theoretical yield) of β-hydroxybutyric acid p-phenetidide are obtained in the form of white crystals, which are sparingly soluble in water and melt at 160°C.
A mixture of 5 g of aluminum amalgam, 5 g of acetoacetic acid p-phenetidide and 50 ml of ethanol are gently heated for 30 minutes. After filtering off the reducing agent with suction, water is added to the filtrate, and the latter is then acidified with 2 N hydrochloric acid. β-Hydroxybutyric acid p-phenetidide melting at 160°C crystallizes in almost quantitative yield in the form of white crystals.
Trademarks
Beelin;Bonanza;Haitmin;Hoe 15239;New isomidon;Ringl-s.
Therapeutic Function
Analgesic
Weltgesundheitsorganisation (WHO)
Bucetin is an analogue of phenacetin. See WHO comment for phenacetin.

3-HYDROXY-P-BUTYROPHENETIDINE Upstream-Materialien And Downstream Produkte

Bucetin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1083-57-4, 3-HYDROXY-P-BUTYROPHENETIDINE Verwandte Suche:

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