Perimetazin

perimetazine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Leptryl ,Roger Bellon, France,1970

• Verwenden

  Perimethazine, is a novel Antipsychotic drug. It has shown to cause sedation, hypothermia, muscle relaxation, and other signs of central depression in rabbits.

• Definition

  ChEBI: Perimetazine is a member of phenothiazines.

• Manufacturing Process

  A solution of 3-methoxy-10-(3-chloro-2-methylpropyl)phenthiazine (9.65 grams) and 4-hydroxypiperidine (6.1 grams) in xylene (10 cc) is heated under reflux for 5 hours. After cooling the mixture is diluted with ether (60 cc) and the basic compounds are extracted by agitation with water (30 cc) and 4 N hydrochloric acid (20 cc). The aqueous acid phase is made alkaline with 4 N sodium hydroxide solution (23 cc) and the liberated base is extracted with ether. The ethereal solution is washed with water (60 cc) and dried over sodium sulfate. Finally the solvent is distilled off on a water-bath.
  The solid residue obtained is recrystallized from a mixture (15:85) of benzene and cyclohexane and there is obtained 3-rnethoxy-10-[2-methyl-3-(4hydroxy-1-piperidyl)-propyl]-phenthiazine (5.7 grams) as a white crystalline powder, MP 137°-138°C.

• Therapeutic Function

  Tranquilizer

perimetazine Upstream-Materialien And Downstream Produkte

Perimetazin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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