Amiphenazol

amiphenazole Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Aamphisol,RJR

• Definition

  ChEBI: Amiphenazole is a member of thiazoles.

• Manufacturing Process

  Thiourea reacted with α-bromophenylacetonitrile and as a result of this reaction 2-(cyanophenylmethyl)isothiourea was obtained.
  By cyclisation of the 2-(cyanophenylmethyl)isothiourea 2,4-diamino-5- phenylthiazole (amiphenazol) was produced.

• Therapeutic Function

  Respiratory stimulant, Barbiturate antagonist, Morphine antagonist

• Synthesis Reference(s)

  Journal of the American Chemical Society, 73, p. 4517, 1951 DOI: 10.1021/ja01154a005

• läuterung methode

  The thiazole crystallises from aqueous EtOH or water. Store it in the dark under N2. The hydrochloride has m 273-274o(dec) (from MeOH/EtOAc), and the picrate has m 189-191o(dec) (from H2O). [Davies et al. J Chem Soc 3491 1950, Dodson & Turner J Am Chem Soc 73 4517 1951, Beilstein 27 III/IV 5139.]

amiphenazole Upstream-Materialien And Downstream Produkte

Amiphenazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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