Dantrolene Struktur

Dantrolen

Bezeichnung:Dantrolen

CAS-Nr7261-97-4

Englisch Name:Dantrolene

CBNumberCB0875659

SummenformelC14H10N4O5

Molgewicht314.25

MOL-Datei7261-97-4.mol

Synonyma

Dantrolen

Dantrolen physikalisch-chemischer Eigenschaften

Schmelzpunkt	279-280°
Siedepunkt	453.94°C (rough estimate)
Dichte	1.3452 (rough estimate)
Brechungsindex	1.6000 (estimate)
storage temp.	Store at -20°C
Löslichkeit	DMSO (Slightly), Methanol (Very Slightly, Sonicated)
pka	7.68±0.10(Predicted)
Aggregatzustand	Solid
Farbe	Yellow to Dark Yellow
Stabilität	Hygroscopic
EPA chemische Informationen	Dantrolene (7261-97-4)

Sicherheit

HS Code	2934990002
Giftige Stoffe Daten	7261-97-4(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Dantrolene Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Dantrium,Norwich Eaton ,US,1974
Verwenden
Dantrolene acts as a skeletal muscle relaxant through inhibition of Ca2+ release through ryanodine receptor channels.
Verwenden
Relaxant (skeletal muscle).
Definition
ChEBI: The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin.
Manufacturing Process
5-(p-Nitrophenyl)-2-furaldehyde (40.0 grams, 0.2 mol) is dissolved in dimethylformamide. An aqueous solution of 1-aminohydantoin hydrochloride (30.0 grams, 0.2 mol) is added. The solution is chilled and diluted with water. The crude material is collected and recrystallized from aqueous dimethylformamide to yield 10.0 grams (16%). MP 279°-280°C. This compound is then converted to the sodium salt.
Trademarks
Dantrium (Procter & Gamble).
Therapeutic Function
Muscle relaxant
Allgemeine Beschreibung
Crystals (in aqueous DMF).
Air & Water Reaktionen
Slightly water soluble. Dantrolene may be sensitive to heat and air .
Reaktivität anzeigen
A nitrated amine derivative. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health Hazard
SYMPTOMS: When ingested, symptoms of exposure may include drowsiness, dizziness, weakness, general malaise, fatigue, diarrhea, constipation, gastrointestinal bleeding, anorexia, abdominal cramps, hepatitis, speech disturbance, seizure, headache, light-headedness, insomnia, tachycardia, phlebitis, mental depression, mental confusion, nervousness, abdominal hair growth, rash, sweating, backache, chills and fever.
Brandgefahr
Flash point data for Dantrolene are not available. Dantrolene is probably combustible.

Dantrolene Upstream-Materialien And Downstream Produkte

Dantrolen Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

7261-97-4, Dantrolene Verwandte Suche:

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