15(S)-HETE

Bezeichnung:15(S)-HETE

CAS-Nr54845-95-3

Englisch Name:15(S)-HETE

CBNumberCB0724870

SummenformelC20H32O3

Molgewicht320.47

MOL-Datei54845-95-3.mol

15(S)-HETE physikalisch-chemischer Eigenschaften

Siedepunkt	487.7±45.0 °C(Predicted)
Dichte	0.984±0.06 g/cm3(Predicted)
Flammpunkt	14℃
storage temp.	-20°C
Löslichkeit	0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml
Aggregatzustand	Liquid.
pka	4.75±0.10(Predicted)
BRN	2470466

Sicherheit

Kennzeichnung gefährlicher	F,Xi
R-Sätze:	11-36/37/38
S-Sätze:	7-16-26-36
RIDADR	UN 1170 3/PG 2
WGK Germany	3

Gefahreninformationscode (GHS)

15(S)-HETE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S7:Behälter dicht geschlossen halten.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes. 15(S)-HETE is present in μg/ml concentrations in the nasal secretions of allergic rhinitis.
Verwenden
15(S)-HETE is an arachidonic acid metabolite with immunosuppressive activity.
Verwenden
15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes. 15(S)-HETE is present in μg/ml concentrations in the nasal secretions of allergic rhinitis.
Definition
ChEBI: An optically active form of 15-HETE having 15(S)-configuration..
Allgemeine Beschreibung
15(S)-HETE is a product of the arachidonic acid pathway. It is synthesized by the human lungs and airway epithelial cells. 15(S)-HETE is a potent mucosecretagogue in human airways. It is a metabolite of 15-lipoxygenase. 15(S)-HETE is an endogenous ligand for peroxisome proliferator-activated receptor γ (PPARγ).
Biochem/physiol Actions
Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2.

15(S)-HETE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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