MOFEBUTAZONE Struktur

Mofebutazon

Bezeichnung:Mofebutazon

CAS-Nr2210-63-1

Englisch Name:MOFEBUTAZONE

CBNumberCB0667894

SummenformelC13H16N2O2

Molgewicht232.28

MOL-Datei2210-63-1.mol

Synonyma

Mofebutazon

Mofebutazon physikalisch-chemischer Eigenschaften

Schmelzpunkt	102-103°
Siedepunkt	374.44°C (rough estimate)
Dichte	1.1099 (rough estimate)
Brechungsindex	1.6450 (estimate)
storage temp.	Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Sparingly)
Aggregatzustand	Solid
pka	5.22±0.10(Predicted)
Farbe	White to Off-White

Sicherheit

Toxizität

LD50 i.v. in mice: 600 mg/kg (Schoetensack)

Gefahreninformationscode (GHS)

MOFEBUTAZONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Butaphen,Wiedenmann
Verwenden
Mofebutazone is an anti-inflammatory drug used on the gastrointestinal and renal tissues.
Definition
ChEBI: A pyrazolidine that is phenylbutazone lacking one of the phenyl substituents. It is used for treatment of joint and muscular pain.
Manufacturing Process
A mixture comprising 108 g of phenyl hydrazine and 216 g of the diethyl ester of n-butylmalonic acid is heated on an oil bath at 170°-180°C for 12 hours. The residue is taken up with water in which an alkaline compound has been dissolved and acetic acid is added to precipitate 4-n-butyl-2-phenylpyrazolidine-3,5-dione. The product is a white crystalline solid having a MP: 103°C. It is soluble in acetone and benzene, soluble in hot condition in methanol and ethanol and insoluble in water.
Trademarks
Arcobutine;Buta lyseen;Chemiartrol;Clinit;Diadin;Fenartril;Jovapyrin;Mobutazone;Mofasal;Mofesal;Monazone;Monbutina;Monobutina;Monofen;Monomil;Monoprine;Monozon;Mozol;Rheuma-cur;Rheumaorctat;Rivodol;Sodepyrine b 1.
Therapeutic Function
Antirheumatic, Analgesic, Antiinflammatory
Weltgesundheitsorganisation (WHO)
Mofebutazone, a pyrazolone with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1962 for the treatment of rheumatic disorders. As it is structurally related to phenylbutazone it is subjected to rigorously restricted indications by some national regulatory authorities. See WHO comment for phenylbutazone.
Clinical Use
Mofebutazone is a nonsteroidal anti-inflammatory drug used as sodium salt for the treatment of mild to moderate pain including inflammatory and degenerative rheumatic disorders and musculoskeletal pain. Mofebutazone can be given by oral, rectal (900–1200 mg/d), or intramuscular administration (650 mg/d).

MOFEBUTAZONE Upstream-Materialien And Downstream Produkte

Mofebutazon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2210-63-1, MOFEBUTAZONE Verwandte Suche:

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