ETILEFRINE-D5 Struktur

Etilefrin

Bezeichnung:Etilefrin

CAS-Nr709-55-7

Englisch Name:ETILEFRINE-D5

CBNumberCB0495639

SummenformelC10H15NO2

Molgewicht181.23

MOL-Datei709-55-7.mol

Synonyma

Etilefrin

Etilefrin physikalisch-chemischer Eigenschaften

Schmelzpunkt	147-148°
Siedepunkt	314.35°C (rough estimate)
Dichte	1.0918 (rough estimate)
Brechungsindex	1.5464 (estimate)
pka	9.81±0.10(Predicted)
LogP	3.2 at 25℃ and pH5.5

Gefahreninformationscode (GHS)

ETILEFRINE-D5 Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Circupon,Troponwerke,W. Germany
Verwenden
Etilefrin is a sympathomimetic drug that increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Etilefrin has both beta 1 and alpha adrenergic effects on humans and is mainly used for the treatment of patients with orthostatic hypotension.
Verwenden
ETILEFRINE-D5 is a sympathomimetic drug that increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Etilefrin has both beta 1 and alpha adrenergic effects on humans and is mainly used for the treatment of patients with orthostatic hypotension.
Definition
ChEBI: 3-[2-(ethylamino)-1-hydroxyethyl]phenol is a member of phenols.
Manufacturing Process
30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and dissolved while warming. After heating for 1 hour under reflux, the acylation is complete. After concentrating the reaction solution, the product is precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2- (N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water, thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan- 1-one, dissolved in a 10-fold amount of water, are added dropwise at room temperature and hydrogenation is carried out until 1 mol of hydrogen has been taken up. After filtering off the catalyst, a further 3 parts of palladium/charcoal are added and hydrogenation is carried out until a further mol of hydrogen has been taken up. The catalyst is separated off and after removal of the solvent the hydrogenation product is reprecipitated from acetone/petroleum ether and from methanol/ether until it is pure according to thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2- ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.
Therapeutic Function
Tranquilizer

ETILEFRINE-D5 Upstream-Materialien And Downstream Produkte

Etilefrin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

709-55-7, ETILEFRINE-D5 Verwandte Suche:

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