BENZIODARONE Struktur

Benziodaron

Bezeichnung:Benziodaron

CAS-Nr68-90-6

Englisch Name:BENZIODARONE

CBNumberCB0330990

SummenformelC17H12I2O3

Molgewicht518.08

MOL-Datei68-90-6.mol

Synonyma

Benziodaron

Benziodaron physikalisch-chemischer Eigenschaften

Schmelzpunkt	167°
Dichte	1.9173 (estimate)
storage temp.	Refrigerator
Löslichkeit	Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
Aggregatzustand	Solid
Farbe	Beige
Wasserlöslichkeit	5.881mg/L(20 ºC)
CAS Datenbank	68-90-6

Sicherheit

HS Code

2906.19.5000

Gefahreninformationscode (GHS)

BENZIODARONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Amplivix,Sigma-Tau
Verwenden
Benziodarone is a uricosuric drug,it is used to effectively to control hyperuricemia in renal transplantation.
Definition
ChEBI: Benziodarone is an aromatic ketone.
Manufacturing Process
The starting product 2-ethyl-3-benzofuranyl p-hydroxyphenyl ketone (benzaron) was prepared in 4 steps:
1. First step was a reaction of salicylic aldehyde with chloroacetone to produce 2-acetyl-1-benzofuran.
2. It was reduced by hydrazine hydrate in an alkaline medium by process of Hyuang-Minlon, J.A.C.S., 1946, 68, 2487 to give 2-ethyl-1-benzofurane.
3. 2-Ethyl-3-(4-methoxybenzoyl)-1-benzofuran was obtained from 2-ethyl-1- benzofuran and 4-methoxy-benzoylchloride in a presence of tin tetrachloride. 4. It was heated with pyridine hydrochloride at 200°-220°C to give 2-ethyl-3- benzofuranyl p-hydroxyphenyl ketone (benzaron) as described in N.P.B.Hoi, C.Beaudet; US Patent No. 3,012,042; Dec. 5, 1961.
Benzaron (1 part) was dissolved in a very slight excess of 3% caustic soda. To this solution is gradually added a slight excess of iodine dissolved in a 25% aqueous solution of potassium iodide. The resultant solution is acidified with a 20% solution of sodium bisulphite, centrifuged, washed with water and then recrystallized in acetic acid to give of 2-ethyl-3-benzofuranyl 4-hydroxy-3,5- diiodophenyl ketone. MP: 167°C.
Therapeutic Function
Coronary vasodilator, Uricosuric
Sicherheitsprofil
A poison bj7 intraperitoneal and intravenous routes. Moderately toxic by ingestion. A flammable liquid. When heated to decomposition it emits toxic vapors of I-.

BENZIODARONE Upstream-Materialien And Downstream Produkte

Benziodaron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

68-90-6, BENZIODARONE Verwandte Suche:

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