LDC1267

LDC1267 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  LDC1267 is a highly selective TAM kinase inhibitor with IC50s of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Low activity against Met, Aurora B, Lck, Src, and CDK8.

• in vitro

  LDC1267 moderately affected proliferation in 11 of 95 different cell lines with IC50 >5 μM. In NKG2D-activated NK cells, it abrogates the inhibitory effect of Gas6 stimulation.

• in vivo

  In B16F10 melanoma-bearing mice, LDC1267 (20 mg/kg, ip) potently enhanced anti-metastatic NK cell activity and resisted tumor metabolism without severe cytotoxicity.

• target

  Target	Value
  Mer (Cell-free assay)	<5 nM
  Tyro3 (Cell-free assay)	8 nM
  Axl (Cell-free assay)	29 nM

LDC1267 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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