S14161 Struktur

S14161

Bezeichnung:S14161

CAS-Nr883046-50-2

Englisch Name:S14161

CBNumberCB02677978

SummenformelC17H14FNO4

Molgewicht315.2957632

MOL-Datei883046-50-2.mol

S14161 physikalisch-chemischer Eigenschaften

Siedepunkt	456.2±45.0 °C(Predicted)
Dichte	1.34±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
Löslichkeit	DMSO: soluble
Aggregatzustand	A solid
Farbe	Yellow

Gefahreninformationscode (GHS)

S14161 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G₁ to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D₁-D₃ expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G₀/G₁ phase in a dose-dependent manner (concentrations tested from 5-10 μM). S14161 induces apoptosis in myeloma and leukemia cell lines (IC₅₀s < 10 μM) but is less toxic to normal hematopoietic cells (IC₂₀ > 25 μM). In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day.
Verwenden
D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM). S14161 induces apoptosis in myeloma and leukemia cell lines (IC50s < 10 μM) but is less toxic to normal hematopoietic cells (IC20 > 25 μM). In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day.[Cayman Chemical]
Verwenden
S14161 is a small-molecule inhibitor of D-cyclin transactivation that displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.
Lager
+4°C

S14161 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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