Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-

Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  WHI-P180 is an inhibitor of multiple kinases with IC50 values of 4.5 nM and 66 nM for RET (c-RET) and KDR, respectively.

• in vivo

  WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following iv, ip, or po administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic ip bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis.

• target

  Target	Value
  RET (Cell-free assay)	4.5 nM
  KDR (Cell-free assay)	66 nM

Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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