15-Lipoxygenase Inhibitor 1

15-Lipoxygenase Inhibitor 1 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  4-MMPB is a selective lipoxygenase 15-lipoxygenase inhibitor with IC50 value of 18 μM. The IC50 values of it against soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1) were 19.5 μM and 19.1 μM, respectively. It has potential for prostate cancer research.

• in vitro

  4-MMPB has an IC ₅₀ of 69.6 μM for DPPH bleaching.
  4-MMPB exhibits cytotoxic activity on human PC-3 and HFF3 cell lines.
  4-MMPB (41.48 μM; 72 hours) induces apoptosis and DNA damage in PC-3 Cells.
  

  Cell Viability Assay

  Cell Line:	DU145 cells, PC-3 cells, HFF3 cells
  Concentration:	9.57 μM, 19.94 μM, 39.88 μM, 79.77 μM, 159.53 μM
  Incubation Time:	24 hours, 48 hours, 72 hours
  Result:	IC 50 s of 79.76 μM (24 hours), 51.05 μM (48 hours) and 41.48 μM (72 hours) for PC-3 cells, and 255.25 μM (24 hours), 130.81 μM (48 hours) and 98.91 μM (72 hours) for HFF3 cells.

• target

  IC50: 18 μM (15-lipoxygenase)

15-Lipoxygenase Inhibitor 1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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