DBeQ

Bezeichnung:DBeQ

CAS-Nr177355-84-9

Englisch Name:DBeQ

CBNumberCB02569682

SummenformelC22H20N4

Molgewicht340.42

MOL-Datei177355-84-9.mol

DBeQ physikalisch-chemischer Eigenschaften

Schmelzpunkt	149 °C
Siedepunkt	573.1±52.0 °C(Predicted)
Dichte	1.259±0.06 g/cm3(Predicted)
storage temp.	room temp
Löslichkeit	DMSO: ≥20mg/mL
Aggregatzustand	powder
pka	7.78±0.30(Predicted)
Farbe	white to beige
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey	QAIMUUJJAJBPCL-UHFFFAOYSA-N
CAS Datenbank	177355-84-9

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36
S-Sätze:	26
WGK Germany	3
HS Code	2933.59.8000

Gefahreninformationscode (GHS)

DBeQ Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
DBeQ (177355-84-9) is a potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 μM. DBeQ blocks ubiquitin-dependent protein clearance pathways. Cell permeable.
Verwenden
The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM). It does not exhibit activity when tested against a panel 170 protein kinases at concentrations as high as 15 μM. At 10 μM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.[Cayman Chemical]
Verwenden
HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.
Biochem/physiol Actions
DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.
Lager
Store at +4°C
Einzelnachweise
1) Chou et al. (2011), Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways; Proc. Natl. Acad. Sci. USA, 108 4834

DBeQ Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Send Inquriy