5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P304+P340：BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P405：Unter Verschluss aufbewahren.

5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Ethyl 5-bromo-2-methylnicotinate is used as a pharmaceutical intermediate.

• Synthese

  To a 250 mL triple-necked flask were added sequentially 4. 9 g of methyl 5-bromo-2-methylnicotinate ( 0. 04 mol), anhydrous ethanol 40 mL, the corresponding amount of concentrated sulfuric acid, and phase transfer catalyst; a stirrer and a distillation apparatus were installed separately. Heat with stirring, gradually increase the temperature, evaporate the ethanol to the required liquid temperature, stop heating, natural cooling, about . 50 C. It is poured out, and the reactants are white solids at room temperature. Neutralize the product with saturated aqueous sodium carbonate to a pH of about 7 (some solid sodium carbonate may be added if the volume is too large) and extract with 20 of chloroform. mL of chloroform, the combined organic layers were transferred to a reduced-pressure distillation flask, the chloroform was recovered at atmospheric pressure and then ethyl 5-bromo-2-methylnicotinate was distilled at reduced pressure, and the 92- to fraction was collected at 1. 06 kPa. The fraction was collected at 1.06 kPa from 92 to , weighed and the yield was calculated.

5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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