(6-Bromo-pyridin-3-yl)-methanol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H318：Verursacht schwere Augenschäden.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

(6-Bromo-pyridin-3-yl)-methanol Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  2-Bromo-5-pyridinemethanol is used as a pharmaceutical intermediate.

• Synthese

  

  149806-06-4

  

  122306-01-8

  General procedure for the synthesis of 2-bromo-5-(hydroxymethyl)pyridine from 2-bromo-5-formylpyridine: Sodium borohydride (4.88 g, 0.026 mol) was added batchwise to a solution of 6-bromonicotinaldehyde (20.0 g, 0.11 mol) in methanol (108 mL) at 20-30 °C. The reaction mixture was stirred at room temperature for 2 hours. Subsequently, the reaction mixture was diluted with saturated aqueous ammonium chloride solution. The mixture was concentrated to remove methanol and the resulting aqueous solution was extracted with ethyl acetate. The organic phase was washed sequentially with saturated aqueous sodium bicarbonate and brine, dried over magnesium sulfate, filtered and concentrated to afford 2-bromo-5-(hydroxymethyl)pyridine (18.61 g, 92% yield) as a light yellow solid.1H-NMR (300 MHz, CDCl3) δ (ppm): 8.36 (d, J = 2.7Hz, 1H), 7.60 (dd, J = 8.1, 2.7Hz, 1H). 2.7 Hz, 1H), 7.49 (d, J = 8.1 Hz, 1H), 4.72 (s, 2H), 1.95 (s, 1H).

• Einzelnachweise

  [1] Patent: WO2013/44360, 2013, A1. Location in patent: Paragraph 000299-000300
  [2] Patent: WO2006/114213, 2006, A1. Location in patent: Page/Page column 29-30
  [3] Patent: WO2012/177603, 2012, A2. Location in patent: Page/Page column 105-108
  [4] Journal of Organic Chemistry, 2004, vol. 69, # 2, p. 250 - 262
  [5] Dalton Transactions, 2012, vol. 41, # 3, p. 1074 - 1081

(6-Bromo-pyridin-3-yl)-methanol Upstream-Materialien And Downstream Produkte

(6-Bromo-pyridin-3-yl)-methanol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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