CGS 21680A

Bezeichnung:CGS 21680A

CAS-Nr124431-80-7

Englisch Name:CGS 21680A

CBNumberCB02130376

SummenformelC23H30ClN7O6

Molgewicht535.99

MOL-Datei124431-80-7.mol

CGS 21680A physikalisch-chemischer Eigenschaften

Schmelzpunkt	204-206°C
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	DMSO (Slightly, Heated), Methanol (Slightly, Heated)
Aggregatzustand	Solid
Farbe	White to Light Beige
Stabilität	Hygroscopic
CAS Datenbank	124431-80-7

Gefahreninformationscode (GHS)

CGS 21680A Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White to Off-White Solid
Verwenden
Adenosine receptors are related to many diseases such as cardiovascular, autoimmune, and cancer. CGS 21680 is a potent and selective agonist of the adenosine A2A receptor, a member of G protein coupled receptor (1,2,3).
Verwenden
A selective A2A receptor agonist.
Verwenden
CGS 21680A is a potent, selective agonist of the adenosine A2A receptor (Ki = 11-46 nM). It is less effective at adenosine A1 and A3 receptors (Kis = 0.5-3.1 and 0.6-1 μM, respectively) and is without effect at adenosine A2B (Ki > 10 μM). CGS 21680A is commonly used to study the actions of the adenosine A2A receptor in cells and tissues.[Cayman Chemical]
Biologische Aktivität
cgs 21680 hcl is a selective agonist of a2 adenosine receptor with ic50 value of 22nm [1].in rat striatal membranes, cgs 21680 potently prevents ligands from binding to a2 adenosine receptors with ic50 value of 22nm. in the binding assay, cgs 21680 shows no effect to other putative neurotransmitter/neuromodulator sites in brain membranes such as adrenergic, dopamine and serotonin. in the rat heart model, cgs 21680 is effective in increasing coronary flow with ec25 value of 2nm [1].
in vivo
the hydrochloride salt of cgs 21680 has potent efficacy to decrease blood pressure in the anesthetized normotensive rat with ed50 value of 9μg/kg. it also causes heart rate increasing up to 15%. besides that, cgs 21680 hcl significantly lower the blood pressure at dose of 10mg/kg in the spontaneously hypertensive rat. a transient elecation of heart rate is also observed at 30 min in the model [1].
Lager
-20°C (desiccate)
Einzelnachweise
[1] hutchison a j, webb r l, oei h h, et al. cgs 21680c, an a2 selective adenosine receptor agonist with preferential hypotensive activity. journal of pharmacology and experimental therapeutics, 1989, 251(1): 47-55.

CGS 21680A Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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