2-Phenoxyphenylboronic acid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P304+P340：BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P405：Unter Verschluss aufbewahren.

2-Phenoxyphenylboronic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Reactant for palladium catalyzed cross-coupling reactions, trifluoromethylation via copper-mediated oxidative cross-coupling, preparation of biologically and pharmacologically active molecules, preparation of pyridazine-based scaffolds as a-helix mimetics.

• Verwenden

  suzuki reaction

• Synthese

  

  5419-55-6

  

  7025-06-1

  

  108238-09-1

  The general procedure for the synthesis of 2-phenoxyphenylboronic acid from triisopropyl borate and 2-bromobiphenyl ether was as follows: 1-bromo-2-phenoxybenzene (0.018 mmol) was dissolved in 100 mL of anhydrous THF and added to an undried 500 mL triple-necked flask. The reaction system was cooled to -78 °C under nitrogen protection and maintained at this temperature for 30 min. Subsequently, n-butyllithium (0.027 mmol) was slowly added dropwise, and after the drop was completed, the reaction was maintained at -78 °C for 3 hours. Next, triisopropyl borate (0.02 mmol) was added dropwise slowly, and after the dropwise addition was completed, the reaction was continued at -78 °C for 2 hours. After that, the reaction was slowly warmed up to room temperature and reacted overnight. The progress of the reaction was monitored by TLC and after confirming the completion of the reaction, the reaction solution was quenched slowly by the addition of water, followed by extraction to dryness to give 2-phenoxyphenylboronic acid (B-1) (0.0144 mmol) in 80% yield. Mass spectral data: 214.06.

• Einzelnachweise

  [1] Patent: CN106565434, 2017, A. Location in patent: Paragraph 0128-0131

2-Phenoxyphenylboronic acid Upstream-Materialien And Downstream Produkte

2-Phenoxyphenylboronic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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