3-Butylidenphthalid

Bezeichnung:3-Butylidenphthalid

CAS-Nr551-08-6

Englisch Name:3-Butylidenephthalide

CBNumberCB0173298

SummenformelC12H12O2

Molgewicht188.22

MOL-Datei551-08-6.mol

Synonyma

3-Butylidenphthalid

3-Butylidenphthalid physikalisch-chemischer Eigenschaften

Schmelzpunkt	82.5°C
Siedepunkt	139-142 °C/5 mmHg (lit.)
Dichte	1.103 g/mL at 25 °C (lit.)
FEMA	3333 \| 3-BUTYLIDENEPHTHALIDE
Brechungsindex	n20/D 1.577(lit.)
Flammpunkt	>230 °F
storage temp.	Refrigerator
Löslichkeit	Chloroform (Slightly), Ethyl Acetate (Slightly)
Aggregatzustand	Oil
Farbe	Colourless to Yellow
Geruch (Odor)	at 10.00 % in dipropylene glycol. herbal lovage celery
Geruchsart	herbal
JECFA Number	1170
BRN	5145
InChIKey	WMBOCUXXNSOQHM-FLIBITNWSA-N
LogP	3.72
CAS Datenbank	551-08-6(CAS DataBase Reference)
EPA chemische Informationen	1(3H)-Isobenzofuranone, 3-butylidene- (551-08-6)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	23
WGK Germany	2
RTECS-Nr.	TI3692500
TSCA	Yes

Gefahreninformationscode (GHS)

3-Butylidenephthalide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
Chemische Eigenschaften
3-Butylidenephthalide has a pervasive warm spicy aroma.
Occurrence
Reported as occurring naturally in the fruits and roots of Ligusticum acutilobum and lovage (Levisticum officinale) seeds, roots and leaves.
Verwenden
3-Butylidenephthalide is a phthalide derivative useful for control of sensation disorder and olfaction disorder.
Definition
ChEBI: A gamma-lactone that is phthalide substituted by a butylidene group at position 3. Isolated from Ligusticum porteri, it exhibits hypoglycemic activity.
Taste threshold values
Taste characteristics at 15 ppm: celery, green, vegetable-like with a herbal nuance.
Allgemeine Beschreibung
3-Butylidenephthalide is a bioactive phthalide compound of Chuanxiong rhizoma, a Chinese herbal medicine used for treating headache obtained from the root of Ligusticum chuanxiong Hort.
Cytotoxicity
The anti-proliferative effects of 3-Butylidenephthalide (n-Butylidenephthalide; BP) on cells from GBM, neuroblastoma, lung cancer, melanoma, teratoma, leukemia, breast cancer and hepatocellular carcinoma, as well as from normal fibroblast and vascular endothelial cells, were determined. The IC50 values of BP after a 48 h incubation with tumor cell lines (IC50: 15–67 μg/mL) were significantly lower than the values for normal fibroblast cells (IC50: >?100 μg/mL, p < 0.0001) or carmustine (BCNU)-treated tumor cells (IC50: 40 ～ 100 μg/mL, p < 0.001; Table 1). In the two normal cell types, vascular endothelial cells (IC50 = 25.0 ± 2.0 μg/mL) were more sensitive to BP than fibroblast cells (IC50 > 100 μg/mL) (p < 0.0001). These experiments showed that BP could induce high cytotoxicity against brain and other tumour cells but only low or no cytotoxicity against normal fibroblast cells.
Sicherheitsprofil
Moderately toxic by ingestion. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
target
Nrf2 | TNF-α | NO | IL Receptor

3-Butylidenephthalide Upstream-Materialien And Downstream Produkte

3-Butylidenphthalid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

551-08-6, 3-Butylidenephthalide Verwandte Suche:

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