Disitertide

Disitertide Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Disitertide is an inhibitor of TGF-β1. It prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter. Treatment with Disitertide at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4.

• Biologische Aktivität

  Disitertide (P144) TFA is a polypeptide inhibitor of transforming growth factor TGFβ1, specifically blocking its interaction with the receptor. Disitertide (P144) is also an inhibitor of PI3K and an inducer of apoptosis.

• in vitro

  Disitertide (100 μg/mL) suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells.
  Disitertide (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance.
  Disitertide (P144, 10 μg/mL to 200 μg/mL) affects proliferation,
  

  Western Blot Analysis

  Cell Line:	Mouse embryo osteoblast precursor MC3T3-E1 cells.
  Concentration:
  Concentration:	100 μg/mL.
  Incubation Time:	4 h.
  Result:	Significantly suppressed the protein expression levels of PI3K and p-Akt, and induced the protein expression of Bax in MC3T3-E1 cells compared with the miR-590 group.

• in vivo

  Disitertide (Topical application, 300 μg/mL) may promote scar maturation and clinical improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment.
  

  Animal Model:	Human hypertrophic scars were implanted in 60 nude mice.
  Dosage:	300 μg/mL was added the Lipogel.
  Administration:	Topical application daily administered.
  Result:	Successful shedding was achieved in 83,3% of the xenografts.

• Lager

  Store at -20°C

Disitertide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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