1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Struktur

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

Bezeichnung:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

CAS-Nr23007-85-4

Englisch Name:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

CBNumberCB0133791

SummenformelC12H16ClN

Molgewicht209.72

MOL-Datei23007-85-4.mol

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	249.0 to 254.0 °C
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Aggregatzustand	White solid
Farbe	white to off-white
BRN	3707312
Stabilität	Light Sensitive
InChI	InChI=1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
InChIKey	KOWJANGMTAZWDT-UHFFFAOYSA-N
SMILES	C1(=CCN(C)CC1)C1C=CC=CC=1.Cl
CAS Datenbank	23007-85-4

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25-39/23/24/25-36/37/38
S-Sätze:	45-39-26
RIDADR	2811
WGK Germany	3
RTECS-Nr.	UT8358950
HS Code	2933.39.9200
HazardClass	6.1(b)
PackingGroup	III

Gefahreninformationscode (GHS)

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
White Solid
Verwenden
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.
Verwenden
MPTP is a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP is metabolized by monoamine oxidase B to produce MPDP+ and MPP+, with MP+ being the active toxic agent. MPP+ induces neurotoxicity primarily by inhibiting complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress. The key features of different neurotoxic models of Parkinson’s disease, including the MPTP model, have been detailed.[Cayman Chemical]
Biochem/physiol Actions
Dopaminergic neurotoxin.
läuterung methode
Purify MPTP by recrystallisation from pKEst ~ Me2CO/isoPrOH. The free base has m 40-42o(from heptane), b 99-100o/1.3mm, 128-132o/12mm, (137-142o/0.8mm), n 25 1.5347. The hydrochloride has m 251-252o(from Me2CO/isoPrOH) [Schmidle & Mansfield J Am Chem Soc 78 425 1956, Defeudis Drug Dev Res 15 1 1988, Beilstein 20 III/IV 3240, 20/7 V 121.]
Einzelnachweise
[1] Lun-Yi Zang, Hara P Misra. “Inactivation of acetylcholinesterase by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride.” Molecular and Cellular Biochemistry 254 1–2 (2003): 131–6.
[2] Gregory L. Willis, Alan D. Robertson. “Recovery from experimental Parkinson’s disease in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride treated marmoset with the melatonin analogue ML-23.” Pharmacology Biochemistry and Behavior 80 1 (2005): Pages 9-26.
[3] Atsushi Fujita. “Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model.” Journal of Neuroinflammation (2018): 227.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

23007-85-4, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Verwandte Suche:

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