Micafungin sodium Struktur

Micafungin sodium

Bezeichnung:Micafungin sodium

CAS-Nr208538-73-2

Englisch Name:Micafungin sodium

CBNumberCB01120439

SummenformelC56H72N9NaO23S

Molgewicht1294.28

MOL-Datei208538-73-2.mol

Micafungin sodium physikalisch-chemischer Eigenschaften

Schmelzpunkt	>180°C (dec.)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
Aggregatzustand	Solid
Farbe	White to Off-White
Stabilität	Hygroscopic
CAS Datenbank	208538-73-2

Gefahreninformationscode (GHS)

Micafungin sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
The semi-synthetic echinocandin antifungal agent, micafungin sodium (15), is a 1,3-β-glucan synthase inhibitor discovered by Fujisawa. It is for the treatment and prevention of infections caused by Aspergillus and Candida such as fungemia, respiratory mycosis and gastrointestinal mycosis.
Chemische Eigenschaften
Off-White Solid
Verwenden
Micafungin is an echinocandin antifungal that inhibits 1,3-β-D-glucan synthesis. It has fungicidal activity against virtually all species of Candida, including those resistant to fluconazole, and is fungistatic against Aspergillus spp.[Cayman Chemical]
Verwenden
An echinocandin antifungal drug which inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall, and represent a valuable treatment option for fungal infections.
Verwenden
Micafungin sodium is the salt of the semi-synthetic cyclic lipopeptide, micafungin, a member of the echinocandin class that was reported in 1999 from Fujisawa in Japan. The sodium salt takes advantage of the aryl sulphate moiety providing improved water solubility and is the preferred salt for pharmaceutical applications. Like all echinocandins, micafungin inhibits the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.
Definition
ChEBI: Micafungin sodium is an organic sodium salt and an antibiotic antifungal drug.
Trademarks
Mycamine(Astellas).
Synthese
The key intermediate for the side chain of micafungin (15) was prepared by regioselective 1,3-dipolar cycloaddition reaction of 4-methoxycarbonylbenzhydroxamic acid chloride (147) and 4-pentyloxyphenylacetylene (148) with TEA in THF. Basic hydrolysis of thus obtained ester 149 , followed by condensation with 1- hydroxybenzotriazole (HOBT) gave the corresponding activated ester 150 in 95% yield. The cyclic peptide core 151, obtained by acylase-catalyzed hydrolysis of the natural product FR901379, was acylated with 150 to give micafungin (15) in 53% yield.

Micafungin sodium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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