2-甲基-2,6-壬二烯-1-胺

2-甲基-2,6-壬二烯-1-胺化学性质

熔点 :150-151°
沸点 :389.35°C (rough estimate)
密度 :0.9978 (rough estimate)
折射率 :1.6280 (estimate)
储存条件 :Store at -20°C
溶解度 :DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
形态 :A crystalline solid
酸度系数(pKa) :14.85±0.70(Predicted)
颜色 :White to off-white
水溶解性 :2.217g/L(25 ºC)
EPA化学物质信息 :2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl- (96-88-8)

2-甲基-2,6-壬二烯-1-胺性质、用途与生产工艺

生物活性 Mepivacaine 是一种酰胺型药剂，可暂时使局部失去知觉。Mepivacaine 与神经元细胞膜上特定的电压门控钠离子通道结合，抑制钠离子内流和膜去极化。
体外研究

Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action.
Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine).
Mepivacaine displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels.

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