化合物YQ128

生物活性靶点体外研究体内研究化合物YQ128 试剂级价格

化合物YQ128

CAS号:2454246-18-3
英文名:YQ128
中文名:化合物YQ128
CBNumber:CB98199880
分子式:C27H29ClN2O4S2
分子量:545.11
MOL File:2454246-18-3.mol

化合物YQ128化学性质

沸点 :705.8±70.0 °C(Predicted)
密度 :1.287±0.06 g/cm3(Predicted)
储存条件 :Store at -20°C
溶解度 :DMSO: 250 mg/mL (458.62 mM)
形态 :A crystalline solid
酸度系数(pKa) :9.32±0.50(Predicted)

化合物YQ128性质、用途与生产工艺

生物活性 YQ128 是有效的，选择性第二代 NLRP3 炎性体抑制剂，IC50 为 0.30 µM。YQ128 能显着和选择性地抑制 IL-1β 的产生，但不抑制 TNF-α 的产生。YQ128 可以穿过血脑屏障到达中枢神经系统。YQ128 具有抗炎活性。
靶点

NLRP3

0.30 μM (IC ₅₀ )

IL-1β

体外研究

YQ128 (0.3-100 µM; 30 mins) dose dependently suppressed the release of IL-1β from peritoneal macrophages upon LPS/ATP challenge with an IC ₅₀ of 1.59 µM.
YQ128 (20 µM; 2 hours) shows no significant toxic effects on hCMEC/D3 cells.

Cell Viability Assay

Cell Line:	Mouse peritoneal macrophages
Concentration:	0.3, 1.0, 3.0, 10, 30, 100 µM
Incubation Time:	30 mins
Result:	Suppressed the release of IL-1β from peritoneal macrophages upon LPS/ATP challenge with an IC ₅₀ of 1.59 µM.

体内研究

YQ128 (iv; 20 mg/kg) has an intermediate terminal plasma half-life (t _1/2 ) of 6.6 hours after iv administration.
YQ128 (oral; 20 mg/kg) shows delayed gastrointestinal absorption with a t _max and c _max of 12 h and 73 ng/mL, respectively. Oral bioavailability (F _oral ) is estimated as 10%.
YQ128 exhibits extensive extravascular distribution with a large steady-state volume of distribution (Vd _ss ) of 8.5 L/kg and rapid total clearance (CL _tot ) of 41 mL/min/kg.
YQ128 (10 mg/kg) has been shown to trigger IL-1β production in a NLRP3- dependent manner in C57BL/6 mice.

Animal Model:	Sprague-Dawley rats (200-250 g)
Dosage:	20 mg/kg (Pharmacokinetic Analysis)
Administration:	Iv
Result:	Had an intermediate terminal plasma half-life (t _1/2 ) of 6.6 hours after iv administration.