ChemicalBook CAS数据库列表 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-
1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-
![1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-,1424635-83-5,结构式](https://www.chemicalbook.com/CAS/20210111/GIF/1424635-83-5.gif)
- CAS号:1424635-83-5
- 英文名:1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-
- 中文名:1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-
- CBNumber:CB98123852
- 分子式:C18H14N4OS
- 分子量:334.39
- MOL File:1424635-83-5.mol
1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-化学性质
- 密度 :1.36±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: 83.33 mg/mL (249.20 mM)
- 形态 :A solid
- 酸度系数(pKa) :12.30±0.40(Predicted)
- 颜色 :White to light yellow
1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-性质、用途与生产工艺
- 生物活性 Lats-IN-1 是一种高效的，ATP 竞争性的 Lats1 和 Lats2 激酶抑制剂。Lats-IN-1 能促进有丝分裂后哺乳动物组织的 Yap 依赖性增殖。
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体外研究
The IC 50 for Lats-IN-1 increases with the ATP concentration.
Lats-IN-1 (10 μM; 24 hours) interferes with the ability of Lats kinases to phosphorylate Yap, with an EC 50 of 510 nM.
Lats-IN-1 causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids.
Lats-IN-1 fosters both the G1-S and G2-M checkpoint transitions and yields supporting cells capable of transdifferentiation.
Cell Proliferation Assay
Cell Line: MCF 10A cells Concentration: 10 μM Incubation Time: 24 hours Result: Decreased the phosphorylation of Yap at residue S127.
1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-上下游产品信息
上游原料
下游产品
1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-138489
- 产品名称：TRULI
- CAS编号：
- 包装：1 mg
- 价格：685元
- 更新日期：2024/11/08
- 产品编号：HY-138489
- 产品名称：1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- Lats-IN-1
- CAS编号：1424635-83-5
- 包装：5mg
- 价格：1800元
1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-生产厂家
- 公司名称：CLEARSYNTH LABS LTD.
- 联系电话：--
- 电子邮件：sales@clearsynth.com
- 国家：印度
- 产品数：6257
- 优势度：58
