ChemicalBook CAS数据库列表 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
- CAS号:65836-72-8
- 英文名:2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
- 中文名:2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
- CBNumber:CB9796621
- 分子式:C11H14ClNO3
- 分子量:243.69
- MOL File:65836-72-8.mol
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE化学性质
- 熔点 :116-118 °C(Solv: carbon tetrachloride (56-23-5))
- 沸点 :425.7±45.0 °C(Predicted)
- 密度 :1.194±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO : ≥ 150 mg/mL (615.54 mM)
- 形态 :Solid
- 酸度系数(pKa) :13.42±0.46(Predicted)
- 颜色 :White to light yellow
安全信息
- 危险品标志 :Xi
- 危险等级 :IRRITANT
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE性质、用途与生产工艺
- 生物活性 DKM 2-93是相对选择性的UBA5抑制剂，IC50值为430 μM。
-
靶点
IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)
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体外研究
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC 50 s of 90 and 30 μM, respectively.
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体内研究
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE上下游产品信息
上游原料
下游产品
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-101836
- 产品名称：2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE DKM 2-93
- CAS编号：65836-72-8
- 包装：50mg
- 价格：660元
- 更新日期：2024/11/08
- 产品编号：HY-101836
- 产品名称：2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE DKM 2-93
- CAS编号：65836-72-8
- 包装：10mM * 1mLin DMSO
- 价格：726元
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE生产厂家
- 公司名称：Carbosynth
- 联系电话：--
- 电子邮件：sales@carbosynth.com
- 国家：英国
- 产品数：6005
- 优势度：58
