ChemicalBook CAS数据库列表 (+/-)-VESAMICOL HYDROCHLORIDE
(+/-)-VESAMICOL HYDROCHLORIDE
- CAS号:120447-62-3
- 英文名:(+/-)-VESAMICOL HYDROCHLORIDE
- 中文名:(+/-)-VESAMICOL HYDROCHLORIDE
- CBNumber:CB9782372
- 分子式:C17H26ClNO
- 分子量:295.85
- MOL File:120447-62-3.mol
(+/-)-VESAMICOL HYDROCHLORIDE化学性质
- 储存条件 :Store at RT
- 溶解度 :aqueous buffers below pH 8: 1 mM
- 形态 :solid
- 颜色 :white
安全信息
- WGK Germany :3
(+/-)-VESAMICOL HYDROCHLORIDE性质、用途与生产工艺
- 生物活性 (±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) 是一种有效的囊泡乙酰胆碱转运 (vesicular acetylcholine transport) 抑制剂，Ki 为 2 nM。(±)-Vesamicol hydrochloride 也对 σ1 和 σ2 受体具有高亲和力，Ki 值分别为 26 nM 和 34 nM。
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靶点
Ki: 2 nM (Vesicular acetylcholine transport), 26 nM (σ1 receptors) and 34 nM (σ2 receptors)
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体外研究
The pharmacological actions of (±)-Vesamicol have been attributed to inhibition of acetylcholine transport into synaptic vesicles and the subsequent quantal release of acetylcholine.
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体内研究
(±)-Vesamicol (3 mg/kg; intraperitoneal injection; once; male Wistar rats) treatment increases the levels of cytosolic acetylcholine (ACh) in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum.
Animal Model: Male Wistar rats (120-300 g) Dosage: 3 mg/kg Administration: Intraperitoneal injection; once Result: The levels of cytosolic acetylcholine (ACh) increased in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum.
(+/-)-VESAMICOL HYDROCHLORIDE上下游产品信息
上游原料
下游产品
(+/-)-VESAMICOL HYDROCHLORIDE生产厂家
- 公司名称：NACALAI
- 联系电话：--
- 电子邮件：info-tech@nacalai.co.jp
- 国家：日本
- 产品数：6046
- 优势度：75
