ChemicalBook CAS数据库列表 3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮
3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮
- CAS号:2109805-87-8
- 英文名:FEN1 Inhibitor C3
- 中文名:3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮
- CBNumber:CB95864132
- 分子式:C15H12N2O4
- 分子量:284.27
- MOL File:2109805-87-8.mol
3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮化学性质
- 储存条件 :Inert atmosphere,Store in freezer, under -20°C
- 溶解度 :DMSO: 250 mg/mL (879.45 mM)
- 形态 :Solid
- 颜色 :Light yellow to yellow
3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮性质、用途与生产工艺
- 生物活性 FEN1-IN-3 (Compound 4) 是一种人类皮瓣内切核酸酶-1 (hFEN1) 抑制剂。FEN1-IN-3 可使 hFEN1 稳定化，EC50 为 6.8 μM。
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体外研究
FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a , both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.
3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮上下游产品信息
上游原料
下游产品
3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-136484
- 产品名称：3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮 FEN1-IN-3
- CAS编号：2109805-87-8
- 包装：5mg
- 价格：790元
- 更新日期：2024/11/08
- 产品编号：HY-136484
- 产品名称：3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮 FEN1-IN-3
- CAS编号：2109805-87-8
- 包装：10mM * 1mLin DMSO
- 价格：869元
3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮生产厂家
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
