亮氨酸脑啡肽
- CAS号:58822-25-6
- 英文名:[LEU5]-ENKEPHALIN
- 中文名:亮氨酸脑啡肽
- CBNumber:CB9475863
- 分子式:C28H37N5O7
- 分子量:555.62
- MOL File:58822-25-6.mol
- 熔点 :130-133 °C
- 比旋光度 :+32.3°(c=9,メタノール)
- 沸点 :998.8±65.0 °C(Predicted)
- 密度 :1.274±0.06 g/cm3(Predicted)
- 储存条件 :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- 溶解度 :≥54.6 mg/mL in H2O; ≥54.8 mg/mL in EtOH; ≥55.6 mg/mL in DMSO
- 形态 :Lyophilized powder
- 酸度系数(pKa) :3.40±0.10(Predicted)
- 颜色 :White to light yellow
- 水溶解性 :Soluble in water (1 mg/ml ).
- 序列 :H-Tyr-Gly-Gly-Phe-Leu-OH
亮氨酸脑啡肽性质、用途与生产工艺
- 药理作用 亮氨酸脑啡肽是一种内源性阿片类肽神经递质,与我们体内的阿片类受体结合,β-casomorphin也是一种来源于牛奶的阿片肽。正如预期的那样,在没有催化剂的情况下进行反应只会形成微量的产物。因此,酰肼/NCS系统为含酪氨酸肽的氯化提供一个非常有效的途径。
- 生物活性 [Leu5]-Enkephalin 是一种具有吗啡药性的五肽。作为阿片受体 (opioid receptors) 激动剂。
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靶点
Human Endogenous Metabolite
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体外研究
Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e.g. K i =18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG of C. maenas .Leucine-enkephalin is a pentapeptides with morphine like properties, naturally present in mammalian brain.
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参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量5.0%~12.0%
水分含量≤8.0%
肽含量≥80.0%
- 更新日期:2024/11/08
- 产品编号:HY-P0288
- 产品名称:[Leu5]-Enkephalin
- CAS编号:
- 包装:5 mg
- 价格:300元
- 更新日期:2024/11/08
- 产品编号:HY-P0288
- 产品名称:亮氨酸脑啡肽 [Leu5]-Enkephalin
- CAS编号:58822-25-6
- 包装:10mM * 1mLin Water
- 价格:367元
- 公司名称:Labinova AB
- 联系电话:--
- 电子邮件:info@labinova.se
- 国家:欧洲
- 产品数:281
- 优势度:64
- 脑肠肽 脑力肽 脑肠肽 (MET(O)5)-ENKEPHALIN TYR-GLY-GLY-PHE-MET-ARG-PHE TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2 DYNORPHIN A (1-7) TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL DYNORPHIN A (1-6) TYR-GLY-GLY-PHE-MET-ARG-ARG TYR-LYS-GLY-(CYCLO(GLU26-LYS29),PRO34)-NEUROPEPTIDE Y (25-36) (D-丙2,D-亮5)-脑啡肽 (D-ALA2 D-LEU5)-脑啡肽乙酸酯 (D-ALA2)-亮氨酸脑啡肽 亮氨酸脑啡肽乙酸酯水合物