PACAP (6-38), human, ovine, rat TFA
- CAS号:
- 英文名:PACAP (6-38), human, ovine, rat TFA
- 中文名:PACAP (6-38), human, ovine, rat TFA
- CBNumber:CB94713787
- 分子式:C???H???N??FO??S
- 分子量:0
- MOL File:Mol file
- 形态 :Solid
- 颜色 :White to off-white
- 序列 :H-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
PACAP (6-38), human, ovine, rat TFA性质、用途与生产工艺
- 生物活性 PACAP (6-38), human, ovine, rat TFA 是一种有效的 PACAP 受体拮抗剂。PACAP (6-38) 作用于 PACAP I 型受体,PACAP II 型受体 VIP1 和 PACAP II 型受体 VIP2,IC50 分别为 30 nM,600 nM 和 40 nM。
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靶点
IC50: 30 nM (PACAP type I receptor), 600 nM (PACAP type II receptor VIP 1 ), 40 nM (PACAP type II receptor VIP 2 )
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体外研究
An increase of dopamine (DA) content by HPLC analysis and/or cell proliferation identified by MTT assay by Dexamethasone (DEX) is also observed which can be inhibited by PACAP (6-38) at concentration sufficient to block PACAP type 1 (PAC1) receptor. Pretreatment with PAC1 receptor antagonist PACAP (6-38) at 0.1 or 1 μM for 2 h significantly blocks this increase of DA content by 1 μM DEX. The MTT assay shows that DEX increases cell proliferation. Moreover, this action is also inhibited by the pre-incubation of PACAP (6-38). PACAP (6-38) at 1μM shows no effect on DA content and cell proliferation for 24 h. However, PACAP (6-38) at 0.3 μM has been mentioned to reduce the spontaneous tyrosine hydroxylase (TH) accumulation in differentiated retinal cultured cells for 5 days.
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体内研究
Intravesical administration of the PAC1 receptor antagonist, PACAP (6-38), significantly increases intercontraction interval (2.0-fold) and void volume (2.5-fold) in NGF-OE mice. Intravesical instillation of PACAP (6-38) also decreases baseline bladder pressure in NGF-OE mice. Intravesical administration of PACAP (6-38) (300 nM) significantly (p≤0.01) reduces pelvic sensitivity in NGF-OE mice but is without effect in WT mice.
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参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
- 更新日期:2024/08/19
- 产品编号:HY-P0220A
- 产品名称:PACAP (6-38), human, ovine, rat TFA PACAP (6-38), human, ovine, rat TFA
- CAS编号:
- 包装:500μg
- 价格:1200元
- 更新日期:2024/08/19
- 产品编号:HY-P0220A
- 产品名称:PACAP (6-38), human, ovine, rat TFA PACAP (6-38), human, ovine, rat TFA
- CAS编号:
- 包装:1mg
- 价格:1600元
- 公司名称:Creative Peptides
- 联系电话:
- 电子邮件:info@creative-peptides.com
- 国家:美国
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- 公司名称:BOC Sciences
- 联系电话:16314854226; +16314854226
- 电子邮件:inquiry@bocsci.com
- 国家:美国
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- 公司名称:MedChemExpress
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- 电子邮件:sales@medchemexpress.com
- 国家:美国
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