ChemicalBook CAS数据库列表 Gap19
Gap19
- CAS号:1507930-57-5
- 英文名:Gap19
- 中文名:Gap19
- CBNumber:CB94632530
- 分子式:C55H96N14O13
- 分子量:1161.46
- MOL File:1507930-57-5.mol
Gap19化学性质
- 沸点 :1511.4±65.0 °C(Predicted)
- 密度 :1.212±0.06 g/cm3(Predicted)
- 储存条件 :-20°C
- 溶解度 :≥58.07 mg/mL in H2O; insoluble in EtOH; ≥26.55 mg/mL in DMSO
- 形态 :powder
- 酸度系数(pKa) :3.30±0.10(Predicted)
- 颜色 :white to off-white
- 水溶解性 :Soluble to 2 mg/ml in water
Gap19性质、用途与生产工艺
- 生物活性 Gap19 是一种衍生自 Cx43 细胞质环 (CL) 九个氨基酸的肽,一种有效的,选择性连接蛋白 43 (Cx43) 半通道阻滞剂。Gap19 可以防止 C 末端 (CT) 与 CL 的分子内相互作用。Gap19 不阻断 GJ 通道或 Cx40/pannexin-1 半通道。Gap19 对心肌具有保护作用。
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靶点
Cx43 Hemichannel
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体外研究
Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake.
Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells.
Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes.
Gap19 (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo.
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体内研究
Gap19 (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth.
Animal Model: C57/BL6 mice Dosage: 25 mg/kg Administration: IV; 10 min before ligation Result: Significantly reduced the infarct size by approximately one-fifth.
Gap19上下游产品信息
上游原料
下游产品
Gap19 试剂级价格
- 更新日期:2024/11/08
- 产品编号:HY-P1136
- 产品名称:Gap19 Gap19
- CAS编号:
- 包装:1 mg
- 价格:3637元
Gap19生产厂家
- 公司名称:CLEARSYNTH LABS LTD.
- 联系电话:--
- 电子邮件:sales@clearsynth.com
- 国家:印度
- 产品数:6257
- 优势度:58