133804-44-1
- CAS号:133804-44-1
- 英文名:5-METHYL-2-(1-PIPERAZINYL)BENZENESULFONIC ACID MONOHYDRATE
- 中文名:133804-44-1
- CBNumber:CB9428157
- 分子式:C11H16N2O3S
- 分子量:256.32
- MOL File:133804-44-1.mol
- 密度 :1.302±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO
- 酸度系数(pKa) :-1.76±0.42(Predicted)
133804-44-1性质、用途与生产工艺
- 生物活性 Caldaret 是一种细胞内 Ca2+ 调节剂,通过反向模式抑制 Na+/Ca2+ 交换作用。
-
靶点
Na + /Ca 2+ exchanger
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体外研究
Caldaret (MCC-135) is demonstrated to restore Ca 2+ -ATPase activity of the sarcoplasmic reticulum (SR) isolated from the myocardium acutely exposed to ischemia and reperfusion in vitro.
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体内研究
Caldaret, an intracellular Ca 2+ handling modulator, limits infarct size of reperfused canine heart. The cardioprotective effect of Caldaret, a novel intracellular Ca 2+ handling modulator that acts through reverse-mode Na + /Ca 2+ exchanger inhibition and potential sarcoplasmic reticulum (SR) Ca 2+ uptake enhancement, against reperfusion injury is investigated. Intravenously infused Caldaret (3 or 30 microg/kg per hour) for 30 min at left circumflex (LCX)-reperfusion markedly reduces infarct size (by 51.3% or 71.9%, respectively). The amelioration of intracellular Ca 2+ handling dysfunction achieved by Caldaret leads to cardioprotective effects against reperfusion injury following prolonged ischemia. Caldaret (MCC-135) is a new potent compound with beneficial effects in heart failure. In diabetic rats, Caldaret decreases TR80 significantly without significant effect on developed tension (DT). Caldaret has minimal effects on SR Ca 2+ uptake in normal rats, that is observed as increased SR Ca 2+ uptake at uptake time of 20 and 30 s at the highest concentration of 10 μM. In diabetic rats, Caldaret increases SR Ca 2+ uptake all over the range of uptake time. Both initial rate of SR Ca 2+ uptake and the amount of Ca 2+ accumulated in the SR with longer uptake time are increased by Caldaret.
- 更新日期:2024/04/30
- 产品编号:HY-100298
- 产品名称:133804-44-1 Caldaret
- CAS编号:133804-44-1
- 包装:5 mg
- 价格:6140元
- 更新日期:2024/04/30
- 产品编号:HY-100298
- 产品名称:133804-44-1 Caldaret
- CAS编号:133804-44-1
- 包装:10 mg
- 价格:8600元
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