异懈皮苷

生物活性靶点体外研究异懈皮苷试剂级价格

异懈皮苷

CAS号:482-35-9
英文名:ISOQUERCITRIN
中文名:异懈皮苷
CBNumber:CB9419348
分子式:C21H20O12
分子量:464.38
MOL File:482-35-9.mol

异懈皮苷化学性质

熔点 :230 °C
沸点 :872.6±65.0 °C(Predicted)
密度 :1.87±0.1 g/cm3(Predicted)
FEMA :4225 | ISOQUERCITRIN, ENZYMATICALLY MODIFIED
储存条件 :2-8°C
溶解度 :DMSO (Slightly), Methanol (Slightly)
形态 :Solid
酸度系数(pKa) :6.17±0.40(Predicted)
颜色 :Light Yellow to Yellow
水溶解性 :slightly soluble in water
BRN :100989
稳定性 :Hygroscopic
InChIKey :OVSQVDMCBVZWGM-QSOFNFLRSA-N
LogP :1.750 (est)

安全信息

危险品标志 :Xi
安全说明 :24/25
WGK Germany :3
RTECS号 :LK8960000
F :10-23
海关编码 :29389090
毒性 :LD50 intraperitoneal in mouse: > 5gm/kg

异懈皮苷性质、用途与生产工艺

生物活性 Isoquercetin (Quercetin 3-glucoside) 是天然存在的多酚，具有抗氧化，抗增殖和抗炎特性。Isoquercetin 通过 Nrf2/ARE 抗氧化剂信号传导途径减轻乙醇诱导的肝毒性，氧化应激和炎症反应。Isoquercetin 通过调节核因子-κB (NF-κB) 转录调节系统调节一氧化氮合酶 2 (NO2) 的表达。Isoquercetin 具有高生物利用度和低毒性，是预防糖尿病妊娠出生缺陷的有希望的候选药物。
靶点
Target Value
Wnt/β-catenin
()

体外研究

Isoquercetin (Quercetin 3-glucoside; 5-20 μM; 24 hours) substantially reduces ethanol-induced cytotoxicity , protects hepatic cells against ethanol-stimulated liver injury. Isoquercetin (10 μM; pre-treat 1 hour) dramatically downregulates the levels of ethanol-induced iNOS protein expression in HepG2 cells.

Cell Viability Assay

Cell Line:	HepG2 cells
Concentration:	5 μM, 10 μM, 20 μM
Incubation Time:	24 hours
Result:	Caused significantly enhanced cell viability as positive controls.