ChemicalBook CAS数据库列表 188404-10-6
188404-10-6
- CAS号:188404-10-6
- 英文名:MAFP
- 中文名:188404-10-6
- CBNumber:CB9395022
- 分子式:C21H36FO2P
- 分子量:370.48
- MOL File:188404-10-6.mol
188404-10-6化学性质
- 沸点 :455.3±34.0 °C(Predicted)
- 密度 :0.960±0.06 g/cm3(Predicted)
- RTECS号 :TA8108000
- 闪点 :-16 °C
- 储存条件 :-70°C
- 溶解度 :DMF: 3 mg/ml; DMSO: 3 mg/ml; Ethanol: 3.5 mg/ml; Ethanol:PBS (pH 7.2) 1:1: .5 mg/ml; PBS (7.2): <1 mg/ml (colloidal suspension
- 形态 :methyl acetate solution
- 颜色 :Light yellow to yellow
- 敏感性 :Air Sensitive
安全信息
- 危险品标志 :F,Xi
- 危险类别码 :11-36-66-67
- 安全说明 :16-26-29-33
- 危险品运输编号 :UN 1231 3/PG 2
- WGK Germany :1
188404-10-6性质、用途与生产工艺
- 生物活性 MAFP (Methyl Arachidonyl Fluorophosphonate) 是选择性，针对活性位点，不可逆的 cPLA2 和 iPLA2 抑制剂。 MAFP也是一种有效的不可逆的 anandamide amidase 抑制剂。
-
靶点
cPLA2, iPLA2, Anandamide amidase
-
体外研究
MAFP inhibits iPLA2, in a concentration-dependent manner with an IC 50 of 5 μM after a 5 min preincubation at 40°C in P388D1 cells. cPLA, is a phospholipid hydrolase using the hydroxyl of serine-228 residue as its catalytic nucleophile. MAFP is also an inhibitor of anandamide amidase and as a ligand for the CB1 cannabinoid receptor. MAFP demonstrates selectivity towards anandamide amidase for which it is approximately 3000 and 30000-fold more potent than it is towards chymotrypsin and trypsin, respectively. MAFP displaces [ 3 H]CP-55940 binding to the CB1 cannabinoid receptor with an IC 50 of 20 nM vs 40 nM for anandamide.
188404-10-6上下游产品信息
上游原料
下游产品
188404-10-6 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-103334
- 产品名称：188404-10-6 MAFP
- CAS编号：
- 包装：1mg (26.99 mM * 100 μL in Methyl acetate)
- 价格：900元
- 更新日期：2024/11/08
- 产品编号：HY-103334
- 产品名称：188404-10-6 MAFP
- CAS编号：
- 包装：5mg (26.99 mM * 500 μL in Methyl acetate)
- 价格：2610元
188404-10-6生产厂家
- 公司名称：Alfa Aesar
- 联系电话：--
- 电子邮件：tech@alfa.com
- 国家：印度
- 产品数：6905
- 优势度：58
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